關節鏡清理術配合鹽酸氨基葡萄糖治療輕度單側膝骨關節炎的療效研究_《華西醫學》

作者：

陳小兵 , 崔靜

阿勒泰地區人民醫院外二科（新疆阿勒泰，836500）;

關鍵詞：

關節鏡清理術鹽酸氨基葡萄糖骨關節炎，膝

DOI：

10.7507/1002-0179.20130487

視頻：

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目的　探討關節鏡清理術配合鹽酸氨基葡萄糖對膝骨關節炎的治療作用。方法　2009年6月－2011年6月納入輕度膝骨關節炎（AhlbackⅠ級）患者135例，隨機分成3組。A組（n=45）接受關節鏡清理術治療；B組（n=45）口服鹽酸氨基葡萄糖膠囊治療；C組（（n=45）先行關節鏡清理術治療，術后口服鹽酸氨基葡萄糖膠囊。觀察3組Lequesne評分和WOMAC指數，用以評價治療效果。結果　成功隨訪患者123例，隨訪時間8個月。治療后各組Lequesne評分和WOMAC指數較治療前均顯著好轉（P＜0.01），其中治療后C組好轉較A組和B組具有顯著性（P＜0.01），但B組和C組之間差異無統計學意義（P＞0.05）。結論　關節鏡清理術配合鹽酸氨基葡萄糖，較之單用關節鏡清理術或鹽酸氨基葡萄糖，對膝骨關節炎的治療有更好的效果。

引用本文： 陳小兵,崔靜. 關節鏡清理術配合鹽酸氨基葡萄糖治療輕度單側膝骨關節炎的療效研究. 華西醫學, 2013, 28(10): 1541-1544. doi: 10.7507/1002-0179.20130487 復制

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4.	Moseley JB, O’malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002, 347(2): 81-88.
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8.	Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18): 2113-2123.
9.	Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial[J]. Lancet, 2001, 357(9252): 251-256.
10.	Spahn G, Mückley T, Kahl E, et al. Factors affecting the outcome of arthroscopy in medial-compartment osteoarthritis of the knee[J]. Arthroscopy, 2006, 22(11): 1233-1240.
11.	Aaron RK, Skolnick AH, Reinert SE. Arthroscopic debridement for osteoarthritis of the knee[J]. J Bone Jt Surg Am, 2006, 88(5): 936-943.
12.	Dervin GF, Stiell IG, Rody K, et al. Effect of arthroscopic débridement for osteoarthritis of the knee on health-related quality of Life[J]. J Bone Joint Surg Am, 2003, 85-A(1): 10-19.
13.	Siparsky P, Ryzewicz M, Peterson B, et al. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications?[J]. Clin Orthop Relat Res, 2007, 455: 107-112.
14.	Dervin GF, Stiell IG, Wells GA, et al. Physicians’ accuracy and interrator reliability for the diagnosis of unstable meniscal tears in patients having osteoarthritis of the knee[J]. Can J Surg, 2001, 44(4): 267-274.
15.	Bernard J, Lemon M, Patterson MH. Arthroscopic washout of the knee: a 5-year survival analysis[J]. Knee, 2004, 11(3): 233-235.
16.	Harrison MM, Morrell J, Hopman WM. Influence of obesity on outcome after knee arthroscopy[J]. Arthroscopy, 2004, 20(7): 691-695.
17.	Fond J, Rodin D, Ahmad S, et al. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2-and 5-year results[J]. Arthroscopy, 2002, 18(8): 829-834.
18.	Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up[J]. Arthroscopy, 2003, 19(1): 13-20.

1. 　Calamia V, Ruiz-Romero C, Rocha B, et al. Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes[J]. Arthritis Res Ther, 2010, 12(4): R138.
2. 　Berenbaum F. New horizons and perspectives in the treatment of osteoarthritis[J]. Arthritis Res Ther, 2008, 10 (Suppl 2): 1.
3. 　Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
4. 　Moseley JB, O’malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002, 347(2): 81-88.
5. 　蘇江, 張晶, 吳侗, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的隨機對照研究[J]. 華西醫學, 2012, 14(12): 34.
6. 　McAlindon T, Formica M, LaValley M, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial[J]. Am J Med, 2004, 117(9): 643-649.
7. 　Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12): 1145-1155.
8. 　Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18): 2113-2123.
9. 　Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial[J]. Lancet, 2001, 357(9252): 251-256.
10. 　Spahn G, Mückley T, Kahl E, et al. Factors affecting the outcome of arthroscopy in medial-compartment osteoarthritis of the knee[J]. Arthroscopy, 2006, 22(11): 1233-1240.
11. 　Aaron RK, Skolnick AH, Reinert SE. Arthroscopic debridement for osteoarthritis of the knee[J]. J Bone Jt Surg Am, 2006, 88(5): 936-943.
12. 　Dervin GF, Stiell IG, Rody K, et al. Effect of arthroscopic débridement for osteoarthritis of the knee on health-related quality of Life[J]. J Bone Joint Surg Am, 2003, 85-A(1): 10-19.
13. 　Siparsky P, Ryzewicz M, Peterson B, et al. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications?[J]. Clin Orthop Relat Res, 2007, 455: 107-112.
14. 　Dervin GF, Stiell IG, Wells GA, et al. Physicians’ accuracy and interrator reliability for the diagnosis of unstable meniscal tears in patients having osteoarthritis of the knee[J]. Can J Surg, 2001, 44(4): 267-274.
15. 　Bernard J, Lemon M, Patterson MH. Arthroscopic washout of the knee: a 5-year survival analysis[J]. Knee, 2004, 11(3): 233-235.
16. 　Harrison MM, Morrell J, Hopman WM. Influence of obesity on outcome after knee arthroscopy[J]. Arthroscopy, 2004, 20(7): 691-695.
17. 　Fond J, Rodin D, Ahmad S, et al. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2-and 5-year results[J]. Arthroscopy, 2002, 18(8): 829-834.
18. 　Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up[J]. Arthroscopy, 2003, 19(1): 13-20.

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關節鏡清理術配合鹽酸氨基葡萄糖治療輕度單側膝骨關節炎的療效研究

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