Experience of Infliximab Infusion Management for Crohn’s Disease_West China Medical Journal

Authors：

LI Luohong , LUO Ou , TANG Li ,  ZHANG Mingguang.

Department of Digestion, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

ZHANG Mingguang., Email: xhkllh80@163.com

Keywords：

英夫利西單抗; 克羅恩病; 護理管理

DOI：

10.7507/1002-0179.20130391

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　探討英夫利西單抗治療克羅恩病（CD）在臨床護理中的有效管理措施。方法　對2011年9月—2012年8月靜脈輸注英夫利西單抗的25例住院患者，在藥物配伍、輸注流程、配制方法等方面予以嚴格管理，并嚴密觀察藥物不良反應和積極做好健康宣教。結果　經過精心的觀察、護理和有效的護理管理措施，25例患者用藥6周后體溫恢復正常，大便次數1～2次/d，大便隱血試驗陰性，腹痛、腹脹癥狀緩解，體重增加2～7 kg。結論　在英夫利西單抗藥物臨床輸注過程中，實施有效的輸注護理管理措施是確保患者治療安全以及提高護理質量的重要保障。

Citation： LI Luohong,LUO Ou,TANG Li,ZHANG Mingguang.. Experience of Infliximab Infusion Management for Crohn’s Disease. West China Medical Journal, 2013, 28(8): 1247-1249. doi: 10.7507/1002-0179.20130391 Copy

1.	Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease. Crohn’s Disease cA2 Study Group[J]. N Engl J Med, 1997, 337(15): 1029-1035.
2.	Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial[J]. Lancet, 2002, 359(9317): 1541-1549.
3.	Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis[J]. New Engl J Med , 2005, 353(23): 2462-2476.
4.	孫怡燕, 吳永發, 徐燦, 等. 英夫利西單抗治療克羅恩病的療效觀察[J]. 第二軍醫大學學報, 2010, 31(3): 338-339.
5.	Schnitzler F, Fidder H, Ferrante M, et al. Long-term outcome of treatment with infliximab in 614 patients with Crohn’s disease: results from a single-centre cohort[J]. Gut, 2009, 58(4): 492-500.
6.	Kraemer M, Kirschmeier A, Marth T. Perioperative adjuvant therapy with infliximab in complicated anal Crohn’s disease[J]. Int J Colorectal Dis, 2008, 23(10): 965-969.
7.	De Ridder L, Rings EH, Damen GM, et al. Infliximab dependency in pediatric Crohn’s disease: long-term follow-up of an unselected cohort[J]. Inflamm Bowel Dis, 2008, 14(3): 353-358.
8.	馬東梅, 張春燕. 56例類風濕關節炎病人輸注類克藥物的觀察和護理[J]. 護理研究, 2009, 23(20): 1837-1838.
9.	馮楠, 戈之錚. 英夫利昔單抗在炎癥性腸病治療中的應用[J]. 國際消化病雜志, 2008, 28(4): 273-276.
10.	Arhur B, Miguel R. Biologic therapy in the management of extraint estinal manifestations of inflammatory bowel disease[J]. Inf lam m Bow el Dis, 2007, 13: 1424-1429.
11.	翁雪玲, 張海嫦, 陳燕. 臨床輸注英夫利西單抗不良反應的預防及護理[J].解放軍護理雜志, 2011, 28(1B): 57-58.

1. 　Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease. Crohn’s Disease cA2 Study Group[J]. N Engl J Med, 1997, 337(15): 1029-1035.
2. 　Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial[J]. Lancet, 2002, 359(9317): 1541-1549.
3. 　Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis[J]. New Engl J Med , 2005, 353(23): 2462-2476.
4. 　孫怡燕, 吳永發, 徐燦, 等. 英夫利西單抗治療克羅恩病的療效觀察[J]. 第二軍醫大學學報, 2010, 31(3): 338-339.
5. 　Schnitzler F, Fidder H, Ferrante M, et al. Long-term outcome of treatment with infliximab in 614 patients with Crohn’s disease: results from a single-centre cohort[J]. Gut, 2009, 58(4): 492-500.
6. 　Kraemer M, Kirschmeier A, Marth T. Perioperative adjuvant therapy with infliximab in complicated anal Crohn’s disease[J]. Int J Colorectal Dis, 2008, 23(10): 965-969.
7. 　De Ridder L, Rings EH, Damen GM, et al. Infliximab dependency in pediatric Crohn’s disease: long-term follow-up of an unselected cohort[J]. Inflamm Bowel Dis, 2008, 14(3): 353-358.
8. 　馬東梅, 張春燕. 56例類風濕關節炎病人輸注類克藥物的觀察和護理[J]. 護理研究, 2009, 23(20): 1837-1838.
9. 　馮楠, 戈之錚. 英夫利昔單抗在炎癥性腸病治療中的應用[J]. 國際消化病雜志, 2008, 28(4): 273-276.
10. 　Arhur B, Miguel R. Biologic therapy in the management of extraint estinal manifestations of inflammatory bowel disease[J]. Inf lam m Bow el Dis, 2007, 13: 1424-1429.
11. 　翁雪玲, 張海嫦, 陳燕. 臨床輸注英夫利西單抗不良反應的預防及護理[J].解放軍護理雜志, 2011, 28(1B): 57-58.

West China Medical Journal

Experience of Infliximab Infusion Management for Crohn’s Disease

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content