白細胞介素-33在自身免疫性疾病發病機制中的作用研究進展_《華西醫學》

作者：

張茹珂 ,  武永康

四川大學華西醫院實驗醫學科臨床免疫實驗室（成都，610041）;

關鍵詞：

白細胞介素33 自身免疫性疾病研究進展

DOI：

10.7507/1002-0179.20130295

視頻：

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摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

自身免疫性疾病（AID）是由自身免疫應答引起的慢性炎癥性疾病，該類疾病大多數原因不明，可能與遺傳、感染及環境等因素有關。白細胞介素-33（IL-33）作為一種炎性細胞因子，通過IL-33/ST2信號通路調節免疫應答，從而參與疾病的發生和發展。AID的病程一般較長并反復遷延，臨床治療困難。研究IL-33與AID之間的關系，為AID致病機理的研究、疾病的診斷和治療提供新的方向。

引用本文： 張茹珂,武永康. 白細胞介素-33在自身免疫性疾病發病機制中的作用研究進展. 華西醫學, 2013, 28(6): 937-939. doi: 10.7507/1002-0179.20130295 復制

1.	Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-l receptor-related protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5): 479-490．.
2.	Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1receptor[J]. FEBS Lett, 1989, 258(2): 301-304．.
3.	Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex[J].Immunol, 2007, 179 (4): 2551-2555.
4.	Dinarello CA. An IL-l family member requires caspase-1 processing and signals through the ST2 receptor[J].Immunity, 2005, 23(5): 46l-462.
5.	Ali S, Huber M, Kollewe C, Bischoff SC, et al. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells[J]. Proc Natl Acad Sci USA, 2007, 104(47): 18660-18665.
6.	Rank MA, Kobayashi T, Kozaki H, et al. IL-33-activated dendritic cells induce an atypical TH2-type response[J]. J Allergy Clin Immunol, 2009, 123(5): 1047-1054.
7.	Miller AM, Xu D, Asquith DL, et al. IL-33 reduces the development of atherosclerosis[J]. J Exp Med, 2008, 205(2): 339-346.
8.	Komai-Koma M, Gilchrist DS, McKenzie AN, et al. IL-33 activates B1 cells and exacerbates contact sensitivity[J]. J Immunol, 2011, 186(4): 2584-2591.
9.	Kurowska-Stolarska M, Kewin P, Murphy G, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4[J]. J Immunol, 2008, 181(7): 4780-4790.
10.	Xu D, Jiang HR, Kewin P, et a1. IL-33 exacerbates antigen-induced arthritis by activating mast cells[J]. Proc Natl Acad Sci USA, 2008, 105(31): l0913-109l8．.
11.	陳立輝, 張源潮, 孟紅艷.檢測早期類風濕關節炎(RA)患者血清中IL-33水平的臨床意義[J].中國醫藥指南, 2012, 15(10): 424-425.
12.	劉玥,周迎春,黃鐘.類風濕性關節炎患者IL-33水平變化與疾病嚴重程度的關系[J].醫學檢驗與臨床, 2012, 23(3): 54-56.
13.	黃鶴卿, 穆榮, 劉霞, 等．白細胞介素-33的測定及其與早期類風濕關節炎相關性的研究[J]. 中華風濕病學雜志, 2010, 14(7): 446-448.
14.	施巍宇, 楊再興. 血清IL-33與系統性紅斑狼瘡的關系研究[J]. 現代檢驗醫學雜志, 2010, 25(5): 5-7.
15.	Mok MY, Huang FP, Lp WK, et al. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus[J]. Rheumatology (Oxford), 2010, 49(3): 520-527.
16.	Manetti M, Ibba-Manneschi L, Liakouli V, et al. The IL1-like cytokine IL 33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis[J]. Ann Rheum Dis, 2010, 69(3): 598-605.
17.	Yanaba K, Yoshizaki A, Asano Y, et al. Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis[J]. Clin Rheumatol, 2011, 30(6): 825-830.
18.	Manetti M, Guiducci S, Ceccarelli C, et al. Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement[J]. Ann Rheum Dis, 2011, 70(10): 1876-1878.
19.	Rankin AL, Mumm JB, Murphy E, et al. IL-33 induces IL-13-dependent cutaneous fibrosis[J]. J Immunol, 2010, 184(3): 1526-1535.
20.	Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation[J]. J Clin Invest, 2006, 116(5): 1218-1222.
21.	IHan GW, Zeng LW, Liang CX, et al. Serum levels of IL-33 is increased in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2011, 30(12): 1583-1588.
22.	ITalabot-Ayer D, McKee T, Gindre P, et al. Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Joint Bone Spine, 2012, 79(1): 32-37.

1. 　Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-l receptor-related protein ST2 and induces T helper type 2-associated cytokines[J]. Immunity, 2005, 23(5): 479-490．.
2. 　Tominaga S. A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1receptor[J]. FEBS Lett, 1989, 258(2): 301-304．.
3. 　Chackerian AA, Oldham ER, Murphy EE, et al. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex[J].Immunol, 2007, 179 (4): 2551-2555.
4. 　Dinarello CA. An IL-l family member requires caspase-1 processing and signals through the ST2 receptor[J].Immunity, 2005, 23(5): 46l-462.
5. 　Ali S, Huber M, Kollewe C, Bischoff SC, et al. IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells[J]. Proc Natl Acad Sci USA, 2007, 104(47): 18660-18665.
6. 　Rank MA, Kobayashi T, Kozaki H, et al. IL-33-activated dendritic cells induce an atypical TH2-type response[J]. J Allergy Clin Immunol, 2009, 123(5): 1047-1054.
7. 　Miller AM, Xu D, Asquith DL, et al. IL-33 reduces the development of atherosclerosis[J]. J Exp Med, 2008, 205(2): 339-346.
8. 　Komai-Koma M, Gilchrist DS, McKenzie AN, et al. IL-33 activates B1 cells and exacerbates contact sensitivity[J]. J Immunol, 2011, 186(4): 2584-2591.
9. 　Kurowska-Stolarska M, Kewin P, Murphy G, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4[J]. J Immunol, 2008, 181(7): 4780-4790.
10. 　Xu D, Jiang HR, Kewin P, et a1. IL-33 exacerbates antigen-induced arthritis by activating mast cells[J]. Proc Natl Acad Sci USA, 2008, 105(31): l0913-109l8．.
11. 　陳立輝, 張源潮, 孟紅艷.檢測早期類風濕關節炎(RA)患者血清中IL-33水平的臨床意義[J].中國醫藥指南, 2012, 15(10): 424-425.
12. 　劉玥,周迎春,黃鐘.類風濕性關節炎患者IL-33水平變化與疾病嚴重程度的關系[J].醫學檢驗與臨床, 2012, 23(3): 54-56.
13. 　黃鶴卿, 穆榮, 劉霞, 等．白細胞介素-33的測定及其與早期類風濕關節炎相關性的研究[J]. 中華風濕病學雜志, 2010, 14(7): 446-448.
14. 　施巍宇, 楊再興. 血清IL-33與系統性紅斑狼瘡的關系研究[J]. 現代檢驗醫學雜志, 2010, 25(5): 5-7.
15. 　Mok MY, Huang FP, Lp WK, et al. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus[J]. Rheumatology (Oxford), 2010, 49(3): 520-527.
16. 　Manetti M, Ibba-Manneschi L, Liakouli V, et al. The IL1-like cytokine IL 33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis[J]. Ann Rheum Dis, 2010, 69(3): 598-605.
17. 　Yanaba K, Yoshizaki A, Asano Y, et al. Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis[J]. Clin Rheumatol, 2011, 30(6): 825-830.
18. 　Manetti M, Guiducci S, Ceccarelli C, et al. Increased circulating levels of interleukin 33 in systemic sclerosis correlate with early disease stage and microvascular involvement[J]. Ann Rheum Dis, 2011, 70(10): 1876-1878.
19. 　Rankin AL, Mumm JB, Murphy E, et al. IL-33 induces IL-13-dependent cutaneous fibrosis[J]. J Immunol, 2010, 184(3): 1526-1535.
20. 　Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation[J]. J Clin Invest, 2006, 116(5): 1218-1222.
21. 　IHan GW, Zeng LW, Liang CX, et al. Serum levels of IL-33 is increased in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2011, 30(12): 1583-1588.
22. 　ITalabot-Ayer D, McKee T, Gindre P, et al. Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J]. Joint Bone Spine, 2012, 79(1): 32-37.

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白細胞介素-33在自身免疫性疾病發病機制中的作用研究進展

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《華西醫學》

白細胞介素-33在自身免疫性疾病發病機制中的作用研究進展

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