單核細胞趨化蛋白-4在系統性紅斑狼瘡中的表達及臨床意義_《華西醫學》

作者：

張杰 ¹ ,  李江濤 ¹ , 楊南萍 ²

1 宜賓市第一人民醫院風濕免疫科（四川宜賓，644000）;2 四川大學華西醫院風濕免疫科;

關鍵詞：

單核細胞趨化蛋白-4 紅斑狼瘡，系統性表達

DOI：

10.7507/1002-0179.20130009

視頻：

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目的　研究C-C亞族趨化因子單核細胞趨化蛋白-4（MCP-4/CCL13）在系統性紅斑狼瘡（SLE）患者外周血的表達水平，并分析MCP-4的水平與狼瘡腎炎的關系，以探討MCP-4在SLE發病機制中可能起的作用。方法　選取2007年9月－2010年8月在四川大學華西醫院和宜賓市第一人民醫院診斷明確的SLE及類風濕關節炎（RA）患者各40例。另收入正常健康對照組（20例），應用酶聯免疫吸附試驗定量方法測定SLE組、RA患者和正常健康對照者血清中MCP-4的水平，SLE患者根據有無腎臟受累分為非狼瘡腎炎組和狼瘡腎炎組，其中非狼瘡腎炎組20例，狼瘡腎炎組20例，并分析SLE組血清MCP-4水平是否與抗核抗體、補體C3、C4等指標及SLE疾病活動指數SLEDAI評分相關性，血清MCP-4水平采用方差分析、LSD-t檢驗和Spearman相關進行統計分析。結果　血清MCP-4水平SLE組為（216.32 ± 12.65）pg/mL，RA組為（203.79 ± 18.64）pg/mL，正常健康對照組為（125.13 ± 11.08）pg/mL。SLE組、RA組血清MCP-4水平與正常健康對照組相比均有統計學意義（P＜0.05），SLE組與RA組比較血清MCP-4水平無統計學意義（P＞0.05）；SLE患者中狼瘡腎炎組與非狼瘡腎炎組比較血清MCP-4水平無統計學意義（P＞0.05）。SLE組血清MCP-4水平與抗核抗體、補體C3、C4等指標及SLEDAI評分無相關性。結論　MCP-4在SLE組患者血清中表達增高，MCP-4可能參與了SLE的發病過程，可能成為SLE新的血清學有用指標并作為治療的靶點。

引用本文： 張杰,李江濤,楊南萍. 單核細胞趨化蛋白-4在系統性紅斑狼瘡中的表達及臨床意義. 華西醫學, 2013, 28(1): 32-35. doi: 10.7507/1002-0179.20130009 復制

1.	Kulkarni O, Pawar RD, Purschke W, et al. Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice[J]. J Am Soc Nephrol, 2007, 18(8): 2350-2358.
2.	Iikuni N, Okamoto H, Yoshio T, et al. Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus[J]. Ann Rheum Dis, 2006, 65(2): 253-256.
3.	劉杰, 孫晗笑. 單核細胞趨化蛋白-1生物學特性及應用研究[J]. 生命的化學，2001, 21(6): 445-447.
4.	Radstake TR, van der Voort R, ten Brummelhuis M, et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors[J]. Ann Rheumatic Dis, 2005, 64(3): 359-367.
5.	Eriksson C, Eneslatt K, Ivanoff J, et al. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus[J]. Lupus, 2003,12(10): 766-774.
6.	Lit LC, Wong CK, Tam LS, et al. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus[J]. Ann Rheum Dis, 2006, 65(2): 209-215.
7.	Lu XY, Zhu CQ, Qian J, et al. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection[J]. Lupus, 2010, 19(6): 689-695.
8.	郝偉麗, 周曉鴻, 鄧丹琪, 等. 治療干預對SLE患者血清和尿液MCP-1水平的影響[J]. 中國皮膚性病學雜志, 2010, 24(8): 705-707.
9.	搖順華. MCP-1及IL-10在狼瘡性腎炎及其相關疾病活動度的臨床意義[J]. 放射免疫學雜志, 2012, 25(2): 199-201.
10.	Singh RG, Usha, Rathore SS, et al. Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare[J]. Lupus, 2012, 21(11): 1214-1218.
11.	Malafronte P, Vieira JM Jr, Pereira AC, et al. Association of the MCP-1 –2518 A/G polymorphism and no association of its receptor CCR2 –64 V/I polymorphism with lupus nephritis[J]. J Rheumatol, 2010, 37(4): 776-782.
12.	Lamkhioued B, Garcia-Zepeda EA, Abi-Younes S, et al. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with induction in epithelial cells and mononuclear cells by proinflammatory cytokines[J]. Am J Respir Crit Care Med, 2000, 162(2): 723-732.
13.	Taha RA, Minshall EM, Leung DY, et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis[J]. J Allergy Clin Immunol, 2000, 105(5): 1002-1007.
14.	Taha RA, Laberge S, Hamid Q, et al. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients[J]. Chest, 2001, 120(2): 595-601.
15.	Iwamoto T, Okamoto H, Iikuni N, et al. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis[J]. Rheumatology, 2006, 45(4): 421-424.
16.	徐婷，顧志峰，吳敏，等. 臍帶間質干細胞移植治療對MRL/lpr狼瘡鼠單核細胞趨化蛋白-1的影響[J]. 交通醫學, 2011, 25(4): 325-332.

1. 　Kulkarni O, Pawar RD, Purschke W, et al. Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice[J]. J Am Soc Nephrol, 2007, 18(8): 2350-2358.
2. 　Iikuni N, Okamoto H, Yoshio T, et al. Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus[J]. Ann Rheum Dis, 2006, 65(2): 253-256.
3. 　劉杰, 孫晗笑. 單核細胞趨化蛋白-1生物學特性及應用研究[J]. 生命的化學，2001, 21(6): 445-447.
4. 　Radstake TR, van der Voort R, ten Brummelhuis M, et al. Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors[J]. Ann Rheumatic Dis, 2005, 64(3): 359-367.
5. 　Eriksson C, Eneslatt K, Ivanoff J, et al. Abnormal expression of chemokine receptors on T-cells from patients with systemic lupus erythematosus[J]. Lupus, 2003,12(10): 766-774.
6. 　Lit LC, Wong CK, Tam LS, et al. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus[J]. Ann Rheum Dis, 2006, 65(2): 209-215.
7. 　Lu XY, Zhu CQ, Qian J, et al. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection[J]. Lupus, 2010, 19(6): 689-695.
8. 　郝偉麗, 周曉鴻, 鄧丹琪, 等. 治療干預對SLE患者血清和尿液MCP-1水平的影響[J]. 中國皮膚性病學雜志, 2010, 24(8): 705-707.
9. 　搖順華. MCP-1及IL-10在狼瘡性腎炎及其相關疾病活動度的臨床意義[J]. 放射免疫學雜志, 2012, 25(2): 199-201.
10. 　Singh RG, Usha, Rathore SS, et al. Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare[J]. Lupus, 2012, 21(11): 1214-1218.
11. 　Malafronte P, Vieira JM Jr, Pereira AC, et al. Association of the MCP-1 –2518 A/G polymorphism and no association of its receptor CCR2 –64 V/I polymorphism with lupus nephritis[J]. J Rheumatol, 2010, 37(4): 776-782.
12. 　Lamkhioued B, Garcia-Zepeda EA, Abi-Younes S, et al. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with induction in epithelial cells and mononuclear cells by proinflammatory cytokines[J]. Am J Respir Crit Care Med, 2000, 162(2): 723-732.
13. 　Taha RA, Minshall EM, Leung DY, et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis[J]. J Allergy Clin Immunol, 2000, 105(5): 1002-1007.
14. 　Taha RA, Laberge S, Hamid Q, et al. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients[J]. Chest, 2001, 120(2): 595-601.
15. 　Iwamoto T, Okamoto H, Iikuni N, et al. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis[J]. Rheumatology, 2006, 45(4): 421-424.
16. 　徐婷，顧志峰，吳敏，等. 臍帶間質干細胞移植治療對MRL/lpr狼瘡鼠單核細胞趨化蛋白-1的影響[J]. 交通醫學, 2011, 25(4): 325-332.

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單核細胞趨化蛋白-4在系統性紅斑狼瘡中的表達及臨床意義

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