Analysis on the Risk Factors of Infection in Late-onset Systemic Lupus Erythematosus Patients_West China Medical Journal

Authors：

LIU Yi , TANG Honghu ,  ZHAO Yi

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

ZHAO Yi, Email: year61@163.com

Keywords：

老年; 紅斑狼瘡，系統性; 感染; 危險因素

DOI：

10.7507/1002-0179.20130008

Video：

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目的　回顧性研究老年系統性紅斑狼瘡（SLE）患者合并感染的危險因素。方法　選取1995年1月－2009年12月間在四川大學華西醫院確診為SLE，起病年齡為50周歲以上的158例患者，收集性別、臨床表現、疾病活動度、實驗室檢查指標、合并癥以及并發癥等進行單因素分析或多因素非條件logistic回歸分析。結果　所納入的158例患者中，合并感染53例（占33.5%），采用單因素分析顯示疾病活動性（P=0.001）、低蛋白血癥（P=0.030）、糖尿病（P=0.003）、肺間質病變（P=0.000）與老年SLE患者感染發生有關。經logistic回歸分析顯示，疾病活動性（OR=7.533，P=0.000）、肺間質病變（OR=19.762，P=0.000）、糖尿病（OR=6.862，P=0.025）是老年SLE患者感染發生的危險因素。結論　積極控制老年SLE的疾病活動度，減少危險因素的發生是控制老年SLE患者并發感染的有效手段。

Citation： LIU Yi,TANG Honghu,ZHAO Yi. Analysis on the Risk Factors of Infection in Late-onset Systemic Lupus Erythematosus Patients. West China Medical Journal, 2013, 28(1): 28-31. doi: 10.7507/1002-0179.20130008 Copy

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1. 　Rovensky J, Tuchynová A. Systemic lupus erythematosus in the elderly[J]. Autoimmun Rev, 2008, 7(3): 235-239.
2. 　Padovan M, Govoni M, Castellino G, et al. Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages[J]. Rheumatol Int, 2007, 27(8): 735-741.
3. 　Boddaert J, Huong DL, Amoura Z, et al. Late-onset systemic lupus erythematosus: a personal series of 47 patients and pooled analysis of 714 cases in the literature[J]. Medicine (Baltimore), 2004, 83(6): 348-359.
4. 　Ho CT, Mok CC, Lau CS, et al. Late onset systemic lupus erythematosus in southern Chinese[J]. Ann Rheum Dis, 1998, 57(7): 437-440.
5. 　Appenzeller S, Pereira DA, Costallat LT. Greater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study[J]. Lupus, 2008, 17(11): 1023-1028.
6. 　Lalani S, Pope J, de Leon F, et al. Clinical features and prognosis of late-onset systemic lupus erythematosus: results from the 1000 faces of lupus study[J]. J Rheumatol, 2010, 37(1): 38-44.
7. 　Chen TL, Wong CH, Lee CH, et al. Systemic lupus erythematosus in the elderly[J]. Int J Gerontol, 2009, 3(2): 108-113.
8. 　Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthritis Rheum, 1997, 40(9): 1725.
9. 　Bernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus[J]. Arthritis Rheum, 2006, 54(8): 2550-2557.
10. 　Gladman DD, Hussain F, Iba?ez D, et al. The nature and outcome of infection in systemic lupus erythematosus[J]. Lupus, 2002, 11(4): 234-239.
11. 　裘昊旻, 宣丹旦, 鄒和建. 系統性紅斑狼瘡合并感染130例回顧性分析[J]. 中華風濕病學雜志, 2009, 13(6): 390-393.
12. 　鄭莉, 王忠明, 林輝. 系統性紅斑狼瘡（SLE）患者合并感染臨床分析[J].華西醫學, 2007, 22(1): 33-34.

West China Medical Journal

Analysis on the Risk Factors of Infection in Late-onset Systemic Lupus Erythematosus Patients

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