Applications and prospects of biodegradable rare earth magnesium alloys as bone implant materials_Journal of Biomedical Engineering

Authors：

YUE Hao ^1,2,3 , ZHU Xinke ^1,2,3 , GAO Zhengchao ^1,3 ,  SUN Zhengming ^1,2,3

1. Department of Orthopedics, Shaanxi Provincial People's Hospital, Xi'an 710068, P. R. China;
2. Graduate School of Xi'an Medical University, Xi'an 710021, P. R. China;
3. Key Laboratory of Basic and Clinical Translation for Bone and Joint Diseases in Shaanxi Province, Xi'an 710068, P. R. China;

Corresponding?author：

Keywords：

Magnesium alloy; Rare earth; Corrosion resistance; Clinical application; Biomaterials

DOI：

10.7507/1001-5515.202508012

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Compared with traditional orthopedic metal implants, magnesium alloys demonstrate superior mechanical strength and biocompatibility, while also exhibiting biodegradability, bone-inducing properties, and antibacterial activity. However, currently developed medical magnesium alloys suffer from insufficient corrosion resistance, failing to meet clinical requirements. Rare earth elements, which can effectively enhance critical properties like corrosion resistance in magnesium alloys, have become the core additive elements for developing new medical magnesium alloys. Consequently, the design, preparation, and clinical translation of rare earth magnesium alloys have garnered significant attention in recent years. This study aims to briefly explore the feasibility, challenges, and future prospects of biodegradable rare earth magnesium alloys as orthopedic internal fixation implants.

Citation： YUE Hao, ZHU Xinke, GAO Zhengchao, SUN Zhengming. Applications and prospects of biodegradable rare earth magnesium alloys as bone implant materials. Journal of Biomedical Engineering, 2025, 42(6): 1309-1314. doi: 10.7507/1001-5515.202508012 Copy

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42.	Shunmugasamy V C, AbdelGawad M, Sohail M U, et al. in vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing. Bioact Mater, 2023, 28: 448-466.
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42. Shunmugasamy V C, AbdelGawad M, Sohail M U, et al. in vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing. Bioact Mater, 2023, 28: 448-466.
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