MUC4 Research Progress in Tumor Molecular Markers_Journal of Biomedical Engineering

Authors：

ZHUHua ,  YOUJinhui

Department of Nuclear Medicine, the Affiliated Hospital of North Sichuan Medical College;Medical Imaging Key Laboratory of Sichuan Province, Nanchong 637007, China;

Corresponding?author：

YOUJinhui, Email: youjh@126.com

Keywords：

mucin antigen 4 (MUC4); malignant tumor; marker; radioimmunoimaging; molecular imaging

DOI：

10.7507/1001-5515.20140044

Video：

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Mucin antigen 4 (MUC4) is a molecular marker for some malignant tumors for early tumor diagnosis, prognosis and targeted therapy. It provides a new research direction in tumor diagnosis and treatment that will have a wide application prospect. In recent years, there has been a large number of research reports on the basic and clinical studies about MUC4, but the molecular imaging study about MUC4 is seldom reported. In this paper the recent research about MUC4 on basic and clinical studies is briefly reviewed, and it is expected to promote the development of tumor molecular imaging.

Citation： ZHUHua, YOUJinhui. MUC4 Research Progress in Tumor Molecular Markers. Journal of Biomedical Engineering, 2014, 31(1): 233-236. doi: 10.7507/1001-5515.20140044 Copy

1.	JULIAN J, CARSON D D.Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells[J]. Biochem Biophys Res Commun,2002,293(4):1183-1190.
2.	姜爭,武林楓. 胰腺癌中MUC4表達的作用及臨床意義[J]. 國際遺傳學雜志,2006,29(2):127-129,158.
3.	陳健,王魯平. 癌基因MUC4研究進展[J].國外醫學腫瘤學分冊,2004,31(增刊):24-27.
4.	王偉藝,項煒,唐文皓,等. 胰腺癌的表達及其臨床相關影響因素的分析[J]. 外科理論與實踐,2012,17(3):243-247.
5.	金鋼,胡先貴,應康,等. 基因表達譜芯片在胰腺癌相關基因篩選中的應用研究[J].第二軍醫大學學報2000,21(9):819-822.
6.	陳健,王魯平,郭瑞峰,等. 食管癌中癌基因MUC4的變化及臨床病理意義[J]. 診斷病理學雜志,2004,11(2):49-51.
7.	ZHU Y,ZHANG J J,ZHU R,et al.The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma[J]. Med Oncol, 2011,28 (Suppl 1):S175-S184.
8.	徐信蘭,張玲玲,孔祥,等.卵巢上皮性腫瘤組織中 MUC4,MUC16 蛋白的表達及臨床意義[J].腫瘤防治研究,2010,37(3):333-335.
9.	JEON J M,LEE H W, PARK J Y,et al. Expression of MUC1 and MUC4 and its prognostic significance in non-small cell lung carcinoma[J].Korean J Pathol, 2010,44(4):397-403.
10.	陳智勇,景在平,鄭建民,等.Mucin4在胰腺癌組織中的表達及其臨床意義[J]. 胰腺病學,2005,5(4):220-223.
11.	陳衍,韓晟,薛妍,等.人MUC4啟動子驅動HSV-TK腺病毒靶向殺傷胃癌細胞的研究[J].現代腫瘤醫學,2012,20(3):442-445.
12.	龔道元,伏紅霞,彭艷,等.血清粘蛋白抗原4對胰腺癌的診斷價值研究[J].臨床檢驗雜志,2011,29(7):533-537.
13.	WANG G,LIPERT R J,JAIN M,et al.Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering[J].Anal Chem,2011,83(7):2554-2561.
14.	ZHANG J, ZHANG X, ZHU Y,et al.Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells[J]. Mol Biol Rep,2010,37(6):2797-2802.
15.	SRIVASTAVA S K,BHARDWAJ A,SINGH S,et al. MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells[J]. Carcinogenesis,2011,32(12):1832-1839.
16.	蘇悅,韓素萍.黏附分子和血管內皮生長因子在卵巢上皮性腫瘤中的表達及臨床意義[J].實用臨床醫藥雜志,2010,4(11):8-11.
17.	徐信蘭,張玲玲,盧丹,等. 卵巢上皮性腫瘤組織中粘蛋白抗原4和核因子-κB/p65蛋白表達及臨床意義[J].實用臨床醫藥雜志,2011,15(11):8-10.
18.	PONNUSAMY M P,LAKSHMANAN I,JAIN M,et al. MUC4 mucin-induced epithelial to mesenchymal transition:a novel mechanism for metastasis of human ovarian cancer cells[J]. Oncogene, 2010,29(42):5741-5754.
19.	BRUYèRE E,JONCKHEERE N,FRéNOIS F,et al.The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties:implication for S100A4 protein[J].Biochem Biophys Res Commun, 2011,413(2):325-329.
20.	CHANDRAKUMAR S, JHALA N C,VENKAT R K, et al. Prognostic value of mucin 4 expression in colorectal adenocarcinomas[J].Cancer, 2010,116(15):3577-3586.
21.	TOMOFUMI H,TSUNENOBU W,MAYUMI M,et al. MUC4:a novel prognostic factor of oral squamous cell carcinoma[J].Int J Cancer,2012,130(8):1768-1776.
22.	SINGH A P,MONIAUX N,CHAUHAN S C,et al. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis[J].Cancer Res,2004,64(2):622-630.
23.	JAIN M,VENKATRAMAN G,MONIAUX N,et al. Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer[J].PLoS One, 2011,6(8):233-244.
24.	翟士軍,章斌,袁航,等.Iodogen法¹²⁵I標記單克隆抗體10D9[J].核技術,2009,32(5):371-374.
25.	LI J, SHI L, WANG C, et al. Preliminary biological evaluation of 125I-labeled anti-carbonic anhydrase Ⅸ monoclonal antibody in the mice bearing HT-29 tumors[J]. Nucl Med Commun, 2011,32(12):1190-1193.
26.	CHOPRA A.¹¹¹In/¹²⁵/¹³¹I-Labeled anti-mucin-1 murine, chimeric or humanized antibody hPAM4[DB/OL].Molecular Imaging and Contrast Agent Database. National Center for Biotechnology Information (NCBI)(2011-07-26)[2012-09-12].http://www.ncbi.nlm.nih.gov/books/NBK57127/.

1. JULIAN J, CARSON D D.Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells[J]. Biochem Biophys Res Commun,2002,293(4):1183-1190.
2. 姜爭,武林楓. 胰腺癌中MUC4表達的作用及臨床意義[J]. 國際遺傳學雜志,2006,29(2):127-129,158.
3. 陳健,王魯平. 癌基因MUC4研究進展[J].國外醫學腫瘤學分冊,2004,31(增刊):24-27.
4. 王偉藝,項煒,唐文皓,等. 胰腺癌的表達及其臨床相關影響因素的分析[J]. 外科理論與實踐,2012,17(3):243-247.
5. 金鋼,胡先貴,應康,等. 基因表達譜芯片在胰腺癌相關基因篩選中的應用研究[J].第二軍醫大學學報2000,21(9):819-822.
6. 陳健,王魯平,郭瑞峰,等. 食管癌中癌基因MUC4的變化及臨床病理意義[J]. 診斷病理學雜志,2004,11(2):49-51.
7. ZHU Y,ZHANG J J,ZHU R,et al.The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma[J]. Med Oncol, 2011,28 (Suppl 1):S175-S184.
8. 徐信蘭,張玲玲,孔祥,等.卵巢上皮性腫瘤組織中 MUC4,MUC16 蛋白的表達及臨床意義[J].腫瘤防治研究,2010,37(3):333-335.
9. JEON J M,LEE H W, PARK J Y,et al. Expression of MUC1 and MUC4 and its prognostic significance in non-small cell lung carcinoma[J].Korean J Pathol, 2010,44(4):397-403.
10. 陳智勇,景在平,鄭建民,等.Mucin4在胰腺癌組織中的表達及其臨床意義[J]. 胰腺病學,2005,5(4):220-223.
11. 陳衍,韓晟,薛妍,等.人MUC4啟動子驅動HSV-TK腺病毒靶向殺傷胃癌細胞的研究[J].現代腫瘤醫學,2012,20(3):442-445.
12. 龔道元,伏紅霞,彭艷,等.血清粘蛋白抗原4對胰腺癌的診斷價值研究[J].臨床檢驗雜志,2011,29(7):533-537.
13. WANG G,LIPERT R J,JAIN M,et al.Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering[J].Anal Chem,2011,83(7):2554-2561.
14. ZHANG J, ZHANG X, ZHU Y,et al.Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells[J]. Mol Biol Rep,2010,37(6):2797-2802.
15. SRIVASTAVA S K,BHARDWAJ A,SINGH S,et al. MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells[J]. Carcinogenesis,2011,32(12):1832-1839.
16. 蘇悅,韓素萍.黏附分子和血管內皮生長因子在卵巢上皮性腫瘤中的表達及臨床意義[J].實用臨床醫藥雜志,2010,4(11):8-11.
17. 徐信蘭,張玲玲,盧丹,等. 卵巢上皮性腫瘤組織中粘蛋白抗原4和核因子-κB/p65蛋白表達及臨床意義[J].實用臨床醫藥雜志,2011,15(11):8-10.
18. PONNUSAMY M P,LAKSHMANAN I,JAIN M,et al. MUC4 mucin-induced epithelial to mesenchymal transition:a novel mechanism for metastasis of human ovarian cancer cells[J]. Oncogene, 2010,29(42):5741-5754.
19. BRUYèRE E,JONCKHEERE N,FRéNOIS F,et al.The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties:implication for S100A4 protein[J].Biochem Biophys Res Commun, 2011,413(2):325-329.
20. CHANDRAKUMAR S, JHALA N C,VENKAT R K, et al. Prognostic value of mucin 4 expression in colorectal adenocarcinomas[J].Cancer, 2010,116(15):3577-3586.
21. TOMOFUMI H,TSUNENOBU W,MAYUMI M,et al. MUC4:a novel prognostic factor of oral squamous cell carcinoma[J].Int J Cancer,2012,130(8):1768-1776.
22. SINGH A P,MONIAUX N,CHAUHAN S C,et al. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis[J].Cancer Res,2004,64(2):622-630.
23. JAIN M,VENKATRAMAN G,MONIAUX N,et al. Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer[J].PLoS One, 2011,6(8):233-244.
24. 翟士軍,章斌,袁航,等.Iodogen法¹²⁵I標記單克隆抗體10D9[J].核技術,2009,32(5):371-374.
25. LI J, SHI L, WANG C, et al. Preliminary biological evaluation of 125I-labeled anti-carbonic anhydrase Ⅸ monoclonal antibody in the mice bearing HT-29 tumors[J]. Nucl Med Commun, 2011,32(12):1190-1193.
26. CHOPRA A.¹¹¹In/¹²⁵/¹³¹I-Labeled anti-mucin-1 murine, chimeric or humanized antibody hPAM4[DB/OL].Molecular Imaging and Contrast Agent Database. National Center for Biotechnology Information (NCBI)(2011-07-26)[2012-09-12].http://www.ncbi.nlm.nih.gov/books/NBK57127/.

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MUC4 Research Progress in Tumor Molecular Markers

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