Interpretation of the <i>Chinese expert consensus on clinical intervention pathway for retinal vein occlusion (2026 supplemented edition)</i>_Chinese Journal of Ocular Fundus Diseases

Authors：

Miao Heng , Li Xiaoxin ,  Zhao Mingwei

Department of Ophthalmology, Peking University People’s Hospital, Beijing Key Laboratory of Ocular Disease and Optometry Science, Beijing 100044, China;

Corresponding?author：

Zhao Mingwei, Email: dr_zhaomingwei@163.com

Keywords：

Retinal vein occlusion; Clinical intervention; Pharmacotherapy; Expert consensus; Interpretation

DOI：

10.3760/cma.j.cn511434-20260625-00274

Video：

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Abstract Full text Figures/Tables Video References Cited by

Macular edema secondary to retinal vein occlusion (RVO) represents the core pathological mechanism underlying vision impairment in affected patients. The 2024 edition of the Expert consensus on clinical diagnosis and treatment path of retinal vein occlusion in China has systematically established a framework for standardized RVO diagnosis and management, emphasizing the importance of systemic factor assessment and whole-course disease management, while also defining the timing and protocols for retinal laser photocoagulation. In recent years, substantial progress has been achieved in the pharmacotherapy of RVO, driven by the expanding array of anti-vascular endothelial growth factor agents, continued optimization of dosing regimens, accumulating clinical evidence for intravitreal corticosteroid implants, and advancing research on prognostic biomarkers, all of which have presented new opportunities and challenges in clinical practice. Against this backdrop, Fundus Disease Group of Ophthalmological Society of Chinese Medical Association, Fundus Disease Group of Ophthalmologist Branch of Chinese Medical Doctor Association, in collaboration with leading national experts, have formulated the Interpretation of the Chinese expert consensus on clinical intervention pathway for retinal vein occlusion (2026 supplemented edition). This interpretive article aims to systematically review and elaborate on the recommendations pertaining to the six core clinical questions addressed in this Consensus, with the goal of assisting ophthalmologists in accurately grasping the essential principles, standardizing clinical decision-making, and thereby promoting continuous improvement of the RVO pharmacotherapy quality management system in China, while safeguarding patient treatment safety and visual outcomes.

Citation： Miao Heng, Li Xiaoxin, Zhao Mingwei. Interpretation of the Chinese expert consensus on clinical intervention pathway for retinal vein occlusion (2026 supplemented edition). Chinese Journal of Ocular Fundus Diseases, 2026, 42(9): 752-755. doi: 10.3760/cma.j.cn511434-20260625-00274 Copy

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2.	Ciulla T, Pollack JS, Williams DF. Visual acuity outcomes and anti-VEGF therapy intensity in macular oedema due to retinal vein occlusion: a real-world analysis of 15613 patient eyes[J]. Br J Ophthalmol, 2021, 105(12): 1696-1704. DOI: 10.1136/bjophthalmol-2020-317337.
3.	Snider MJE, Bheemidi AR, Muste JC, et al. Meta-analyses of two treatment regimens for retinal vein occlusion[J]. Ophthalmic Surg Lasers Imaging Retina, 2023, 54(4): 244-250. DOI: 10.3928/23258160-20230320-01.
4.	Chen KY, Chan HC, Chan CM. Effectiveness and safety of anti-vascular endothelial growth factor therapies for macular edema in retinal vein occlusion: a systematic review and network meta-analysis of randomized controlled trials[J]. Surv Ophthalmol, 2025, 70(6): 1067-1089. DOI: 10.1016/j.survophthal.2025.05.008.
5.	Namvar E, Yasemi M, Nowroozzadeh MH, et al. Intravitreal injection of anti-vascular endothelial growth factors combined with corticosteroids for the treatment of macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis[J]. Semin Ophthalmol, 2024, 39(1): 109-119. DOI: 10.1080/08820538.2023.2249527.
6.	Lent-Schochet D, Avaylon J, Nguyen M, et al. OCT predictors of treatment discontinuation in eyes with retinal vein occlusion and macular edema[J]. Ophthalmol Retina, 2023, 7(5): 462-464. DOI: 10.1016/j.oret.2022.12.011.

1. 中華醫學會眼科學分會眼底病學組, 中國醫師協會眼科醫師分會眼底病專業委員會, 《中國視網膜靜脈阻塞臨床干預路徑專家共識(2026補充版)》專家組. 中國視網膜靜脈阻塞臨床干預路徑專家共識(2026補充版)[J]. 中華眼底病雜志, 2026, 42(8): 649-660. DOI:10.3760/cma.j.cn511434-20260625-00275.Fundus Disease Group of Ophthalmological Society of Chinese Medical Association, Fundus Disease Group of Ophthalmologist Branch of Chinese Medical Doctor Association, Expert Group of Chinese Expert Consensus on Clinical Intervention Pathway for Retinal Vein Occlusion (2026 Supplemented Edition)[J]. Chin J Ocul Fundus Dis, 2026, 42(8): 649-660. DOI:10.3760/cma.j.cn511434-20260625-00275.
2. Ciulla T, Pollack JS, Williams DF. Visual acuity outcomes and anti-VEGF therapy intensity in macular oedema due to retinal vein occlusion: a real-world analysis of 15613 patient eyes[J]. Br J Ophthalmol, 2021, 105(12): 1696-1704. DOI: 10.1136/bjophthalmol-2020-317337.
3. Snider MJE, Bheemidi AR, Muste JC, et al. Meta-analyses of two treatment regimens for retinal vein occlusion[J]. Ophthalmic Surg Lasers Imaging Retina, 2023, 54(4): 244-250. DOI: 10.3928/23258160-20230320-01.
4. Chen KY, Chan HC, Chan CM. Effectiveness and safety of anti-vascular endothelial growth factor therapies for macular edema in retinal vein occlusion: a systematic review and network meta-analysis of randomized controlled trials[J]. Surv Ophthalmol, 2025, 70(6): 1067-1089. DOI: 10.1016/j.survophthal.2025.05.008.
5. Namvar E, Yasemi M, Nowroozzadeh MH, et al. Intravitreal injection of anti-vascular endothelial growth factors combined with corticosteroids for the treatment of macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis[J]. Semin Ophthalmol, 2024, 39(1): 109-119. DOI: 10.1080/08820538.2023.2249527.
6. Lent-Schochet D, Avaylon J, Nguyen M, et al. OCT predictors of treatment discontinuation in eyes with retinal vein occlusion and macular edema[J]. Ophthalmol Retina, 2023, 7(5): 462-464. DOI: 10.1016/j.oret.2022.12.011.

Chinese Journal of Ocular Fundus Diseases

Interpretation of the Chinese expert consensus on clinical intervention pathway for retinal vein occlusion (2026 supplemented edition)

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