Proper use of examination of intraocular fluid to assist precise diagnosis and treatment of vitreoretinal diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

 Tao Yong , Shi Yanhong

Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;

Corresponding?author：

Tao Yong, Email: taoyong@bjcyh.com

Keywords：

Aqueous humor; Retinal diseases; Cytokines; Editorial; Examination of intraocular fluid

DOI：

10.3760/cma.j.cn511434-20210315-00134

Video：

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There are many types of fundus diseases and their causes are complex. They can be caused by metabolic factors or inflammatory factors. Fundus examination and imaging examination tools are the main methods for diagnosing fundus diseases. However, in terms of determining the cause and early diagnosis, if the intraocular fluid detection technology can be reasonably combined, the advantages will be greater. Intraocular fluid is the general term for fluid in the eyeball, including aqueous humor, vitreous humor, etc. The molecular components that can be tested include DNA, RNA, antigens, antibodies, and cytokines. With the advancement of molecular testing technology and equipment, intraocular fluid testing as an evidence-based method has gradually been incorporated into the consensus and guidelines of more fundus disease experts, and is mainly used for infectious fundus diseases and camouflage syndromes. Reasonable use of intraocular fluid testing can help improve the personalized diagnosis and treatment of fundus diseases and reduce unnecessary drug overuse. However, it is worth noting that intraocular fluid detection is only one of many tools and cannot replace other examinations and clinical experience. Excessive intraocular fluid testing not only increases the risk of clinical infections because of invasiveness, but also increases the burden on patients.

Citation： Tao Yong, Shi Yanhong. Proper use of examination of intraocular fluid to assist precise diagnosis and treatment of vitreoretinal diseases. Chinese Journal of Ocular Fundus Diseases, 2021, 37(7): 497-502. doi: 10.3760/cma.j.cn511434-20210315-00134 Copy

1.	De Simone L, Belloni L, Aldigeri R, et al. Aqueous tap and rapid diagnosis of cytomegalovirus anterior uveitis: the reggio emilia experience[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(1): 181-186. DOI: 10.1007/s00417-018-4180-9.
2.	Martín Ramírez A, Carde?oso Domingo L, González Guijarro JJ. PCR multiplex for CMV detection in patients with anterior uveitis[J]. Ocul Immunol Inflamm, 2019, 27(2): 197-202. DOI: 10.1080/09273948.2018.1438633.
3.	Chee SP, Bacsal K, Jap A, et al. Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients[J]. Am J Ophthalmol, 2008, 145(5): 834-840. DOI: 10.1016/j.ajo.2007.12.015.
4.	Iyer JV, Agrawal R, Yeo TK, et al. Aqueous humor immune factors and cytomegalovirus (CMV) levels in CMV retinitis through treatment-the CRIGSS study[J]. Cytokine, 2016, 84: 56-62. DOI: 10.1016/j.cyto.2016.05.009.
5.	Mitchell SM, Fox JD. Aqueous and vitreous humor samples for the diagnosis of cytomegalovirus retinitis[J]. Am J Ophthalmol, 1995, 120(2): 252-253. DOI: 10.1016/s0002-9394(14)72618-2.
6.	Yamamoto N, Wakabayashi T, Murakami K, et al. Detection of CMV DNA in the aqueous humor of AIDS patients with CMV retinitis by AMPLICOR CMV test[J]. Ophthalmologica, 2003, 217(1): 45-48. DOI: 10.1159/000068245.
7.	Neumann R, Barequet D, Rosenblatt A, et al. Herpetic anterior uveitis-analysis of presumed and PCR proven cases[J]. Ocul Immunol Inflamm, 2019, 27(2): 211-218. DOI: 10.1080/09273948.2018.1483521.
8.	Siverio Júnior CD, Imai Y, Cunningham ET Jr. Diagnosis and management of herpetic anterior uveitis[J]. Int Ophthalmol Clin, 2002, 42(1): 43-48. DOI: 10.1097/00004397-200201000-00007.
9.	郭源源, 朱丹, 陶勇. 急性視網膜壞死的研究進展[J]. 中華眼科醫學雜志(電子版), 2013, 3(4): 236-239. DOI: 10.3877/cma.j.issn.2095-2007.2013.04.013.Guo YY, Zhu D, Tao Y. Research progress on acute retinal necrosis[J]. Chin J Ophthalmol Med (Electronic Edition), 2013, 3(4): 236-239. DOI: 10.3877/cma.j.issn.2095-2007.2013.04.013.
10.	Abe T, Tsuchida K, Tamai M. A comparative study of the polymerase chain reaction and local antibody production in acute retinal necrosis syndrome and cytomegalovirus retinitis[J]. Graefe's Arch Clin Exp Ophthalmol, 1996, 234(7): 419-424. DOI: 10.1007/BF02539407.
11.	Sugita S, Shimizu N, Watanabe K, et al. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis[J]. Br J Ophthalmol, 2008, 92(7): 928-932. DOI: 10.1136/bjo.2007.133967.
12.	陶勇. 眼內液病原學檢測的研究進展[J]. 中華眼科雜志, 2018, 54(7): 551-556. DOI: 10.3760/cma.j.issn.0412-4081.2018.07.019.Tao Y. Research on examination of intraocular fluid for diagnosis of infectious ocular diseases[J]. Chin J Ophthalmol, 2018, 54(7): 551-556. DOI: 10.3760/cma.j.issn.0412-4081.2018.07.019.
13.	Rishi E, Rishi P, Therese KL, et al. Culture and reverse transcriptase polymerase chain reaction (RT-PCR) proven mycobacterium tuberculosis endophthalmitis: a case series[J]. Ocul Immunol Inflamm, 2018, 26(2): 220-227. DOI: 10.1080/09273948.2016.1207786.
14.	Durand ML. Bacterial and fungal endophthalmitis[J]. Clin Microbiol Rev, 2017, 30(3): 597-613. DOI: 10.1128/CMR.00113-16.
15.	Wittenberg LA, Maberley DA, Ma PE, et al. Contribution of vitreous cytology to final clinical diagnosis fifteen-year review of vitreous cytology specimens from one institution[J]. Ophthalmology, 2008, 115(11): 1944-1950. DOI: 10.1016/j.ophtha.2008.05.022.
16.	Oahalou A, Schellekens PA, de Groot-Mijnes JD, et al. Diagnostic pars plana vitrectomy and aqueous analyses in patients with uveitis of unknown cause[J]. Retina, 2014, 34(1): 108-114. DOI: 10.1097/IAE.0b013e31828e6985.
17.	Margolis R, Brasil OF, Lowder CY, et al. Vitrectomy for the diagnosis and management of uveitis of unknown cause[J]. Ophthalmology, 2007, 114(10): 1893-1897. DOI: 10.1016/j.ophtha.2007.01.038.
18.	Schoenberger SD, Kim SJ, Thorne JE, et al. Diagnosis and treatment of acute retinal necrosis: a report by the American academy of ophthalmology[J]. Ophthalmology, 2017, 124(3): 382-392. DOI: 10.1016/j.ophtha.2016.11.007.
19.	Hsiao YT, Kuo MT, Chiang WY, et al. Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction[J/OL]. BMC Ophthalmol, 2019, 19(1): 87[2019-04-03]. https://pubmed.ncbi.nlm.nih.gov/30943921/. DOI: 10.1186/s12886-019-1093-2.
20.	Bispo P, Davoudi S, Sahm ML, et al. Rapid detection and identification of uveitis pathogens by qualitative multiplex real-time PCR[J]. Invest Ophthalmol Vis Sci, 2018, 59(1): 582-589. DOI: 10.1167/iovs.17-22597.
21.	Bagyalakshmi R, Madhavan HN, Therese KL. Development and application of multiplex polymerase chain reaction for the etiological diagnosis of infectious endophthalmitis[J]. J Postgrad Med, 2006, 52(3): 179-182.
22.	Nakano S, Sugita S, Tomaru Y, et al. Establishment of multiplex solid-phase strip PCR test for detection of 24 ocular infectious disease pathogens[J]. Invest Ophthalmol Vis Sci, 2017, 58(3): 1553-1559. DOI: 10.1167/iovs.16-20556.
23.	Notomi T, Okayama H, Masubuchi H, et al. Loop-mediated isothermal amplification of DNA[J/OL]. Nucleic Acids Res, 2000, 28(12): E63[2000-06-15]. https://pubmed.ncbi.nlm.nih.gov/10871386/. DOI: 10.1093/nar/28.12.e63.
24.	Gudiseva HV, Berry JL, Polski A, et al. Next-generation technologies and strategies for the management of retinoblastoma[J/OL]. Genes (Basel), 2019, 10(12): 1032[2019-12-11]. https://pubmed.ncbi.nlm.nih.gov/31835688/. DOI: 10.3390/genes10121032.
25.	Mishra D, Satpathy G, Chawla R, et al. Utility of broad-range 16S rRNA PCR assay versus conventional methods for laboratory diagnosis of bacterial endophthalmitis in a tertiary care hospital[J]. Br J Ophthalmol, 2019, 103(1): 152-156. DOI: 10.1136/bjophthalmol-2018-312877.
26.	Srinivasan R, Karaoz U, Volegova M, et al. Use of 16S rRNA gene for identification of a broad range of clinically relevant bacterial pathogens[J/OL]. PLoS One, 2015, 10(2): e0117617[2015-02-06]. https://pubmed.ncbi.nlm.nih.gov/25658760/. DOI: 10.1371/journal.pone.0117617.
27.	Ogawa M, Sugita S, Watanabe K, et al. Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA[J]. Graefe's Arch Clin Exp Ophthalmol, 2012, 250(12): 1877-1883. DOI: 10.1007/s00417-012-2015-7.
28.	Ruokonen PC, Metzner S, Ucer A, et al. Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis[J]. Graefe's Arch Clin Exp Ophthalmol, 2010, 248(4): 565-571. DOI: 10.1007/s00417-009-1239-7.
29.	Kashiwagi K, Gohdo T, Sato S, et al. Detection of HIV-RNA in aqueous humor and subretinal fluid in an HIV carrier with rhegmatogenous retinal detachment[J]. Jpn J Ophthalmol, 2000, 44(6): 687-689. DOI: 10.1016/s0021-5155(00)00278-1.
30.	Kolomeyer AM, Murphy KM, Traband A, et al. Beta-D-glucan testing in patients with fungal endophthalmitis[J]. Retina, 2018, 38(4): 650-659. DOI: 10.1097/IAE.0000000000002049.
31.	劉媛. G實驗在早期診斷深部真菌感染中的臨床意義[J]. 臨床醫學工程, 2017, 24(9): 1331-1332. DOI: 10.3969/j.issn.1674-4659.2017.09.1331.Liu Y. Clinical significance of G-test in early diagnosis of deep fungal infection[J]. Clinical Medical & Engineering, 2017, 24(9): 1331-1332. DOI: 10.3969/j.issn.1674-4659.2017.09.1331.
32.	謝莉萍, 劉霆, 孟文彤, 等. 血清半乳甘露聚糖檢測血液病患者侵襲性曲霉菌病的價值[J]. 中華內科雜志, 2006, 45(12): 992-995. DOI: 10.3760/j.issn: 0578-1426.2006.12.007.Xie LP, Liu T, Meng WT, et al. The value of serum galactomannan antigen for detection of invasive aspergillosis in hematological patients[J]. Chinese J Intern Med, 2006, 45(12): 992-995. DOI: 10.3760/j.issn: 0578-1426.2006.12.007.
33.	方靖, 許淑娣. 侵襲性真菌感染患者肺泡灌洗液中半乳甘露聚糖的水平變化及臨床意義[J]. 臨床肺科雜志, 2015, 20(7): 1262-1265. DOI: 10.3969/j.issn.1009-6663.2015.07.032.Fang J, Xu SD. Diagnostic value of galactomannan in bronchoalveolar lavage for invasive fungal disease[J]. Journal of Clinical Pulmonary Medicine, 2015, 20(7): 1262-1265. DOI: 10.3969/j.issn.1009-6663.2015.07.032.
34.	Maldonado RF, Sá-Correia I, Valvano MA. Lipopolysaccharide modification in gram-negative bacteria during chronic infection[J]. FEMS Microbiol Rev, 2016, 40(4): 480-493. DOI: 10.1093/femsre/fuw007.
35.	Wang ZJ, Zhou M, Cao WJ, et al. Evaluation of the goldmann-witmer coefficient in the immunological diagnosis of ocular toxocariasis[J]. Acta Trop, 2016, 158: 20-23. DOI: 10.1016/j.actatropica.2016.02.013.
36.	Wang H, Tao Y. Clinical features and prognostic factors in northern Chinese patients with peripheral granuloma type of ocular toxocariasis: a retrospective cohort study[J]. Ocul Immunol Inflamm, 2020, 13: 1-6. DOI: 10.1080/09273948.2020.1804592.
37.	Mathis T, Beccat S, Sève P, et al. Comparison of immunoblotting (IgA and IgG) and the goldmann-witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients[J]. Br J Ophthalmol, 2018, 102(10): 1454-1458. DOI: 10.1136/bjophthalmol-2017-311528.
38.	趙瀟, 顏華. 血管內皮生長因子在外傷性增生性玻璃體視網膜病變發病機制中的作用研究進展[J]. 中華眼底病雜志, 2018, 34(2): 187-190. DOI: 10.3760/cma.j.issn.1005-1015.2018.02.023.Zhao X, Yan H. Role of vascular endothelial growth factor in the pathogenesis of traumatic proliferative vitreoretinopathy[J]. Chin J Ocul Fundus Dis, 2018, 34(2): 187-190. DOI: 10.3760/cma.j.issn.1005-1015.2018.02.023.
39.	Morescalchi F, Duse S, Gambicorti E, et al Proliferative vitreoretinopathy after eye injuries: an overexpression of growth factors and cytokines leading to a retinal keloid[J/OL]. Mediators Inflamm, 2013, 2013: 269787[2013-09-30]. https://pubmed.ncbi.nlm.nih.gov/24198445/. DOI: 10.1155/2013/269787.
40.	連海燕, 陳曉, 丁琴, 等. 傳統激光光凝與閾值下微脈沖激光光凝對增生型糖尿病視網膜病變玻璃體液中血管內皮生長因子、白細胞介素-33及一氧化氮濃度的影響[J]. 中華眼底病雜志, 2019, 35(2): 124-128. DOI: 10.3760/cma.j.issn.1005-1015.2019.02.004.Lian HY, Chen X, Ding Q, et al. Effects of conventional laser photocoagulation and subthreshold micropulse laser photocoagulation on concentration of vascular endothelial growth factor, interleukin-33 and NO in vitreous of proliferative diabetic retinopathy eyes[J]. Chin J Ocul Fundus Dis, 2019, 35(2): 124-128. DOI: 10.3760/cma.j.issn.1005-1015.2019.02.004.
41.	Holland GN. Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society[J]. Am J Ophthalmol, 1994, 117(5): 663-667. DOI: 10.1016/s0002-9394(14)70075-3.
42.	Takase H, Okada AA, Goto H, et al. Development and validation of new diagnostic criteria for acute retinal necrosis[J]. Jpn J Ophthalmol, 2015, 59(1): 14-20. DOI: 10.1007/s10384-014-0362-0.
43.	Winterhalter S, Stuebiger N, Maier AK, et al. Acute retinal necrosis: diagnostic and treatment strategies in Germany[J]. Ocul Immunol Inflamm, 2016, 24(5): 537-543. DOI: 10.3109/09273948.2015.1034375.
44.	浙江省醫學會熱帶病與寄生蟲病分會艾滋病學組. 艾滋病合并巨細胞病毒視網膜炎診治浙江省專家共識[J]. 中華臨床感染病雜志, 2019, 12(5): 331-338. DOI: 10.3760/cma.j.issn.1674-2397.2019.05.002.AIDS Group, Society of Tropical Diseases and Parasitology of Zhejiang Medical Association. Zhejiang expert consensus on diagnosis and treatment of cytomegalovirus retinitis in AIDS patients[J]. Chin J Clin Infect Dis, 2019, 12(5): 331-338. DOI: 10.3760/cma.j.issn.1674-2397.2019.05.002.
45.	余盈盈, 趙明威, 苗恒. 基于房水病毒學和炎性細胞因子檢測的巨細胞病毒性視網膜炎治療模式的初步研究[J]. 中華眼底病雜志, 2020, 36(1): 1-4. DOI: 10.3760/cma.j.issn.1005-1015.2020.01.001.Yu YY, Zhao MW, Miao H. Regime for cytomegalovirus retinitis based on aqueous virology and inflammatory cytokine determination[J]. Chin J Ocul Fundus Dis, 2020, 36(1): 1-4. DOI: 10.3760/cma.j.issn.1005-1015.2020.01.001.
46.	毛菲菲, 孫揮宇, 李丹, 等. 獲得性免疫缺陷綜合征患者前房水巨細胞病毒聚合酶鏈反應檢測[J]. 中華眼底病雜志, 2015, 31(6): 564-566. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.013.Mao FF, Sun HY, Li D, et al. Detection of cytomegalovirus by polymerase chain reaction in aqueous samples from patients with acquired immune deficiency syndrome[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 564-566. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.013.
47.	McCann JD, Margolis TP, Wong MG, et al. A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis[J]. Am J Ophthalmol, 1995, 120(2): 219-226. DOI: 10.1016/s0002-9394(14)72610-8.
48.	Hoang-Xuan K, Bessell E, Bromberg J, et al. Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology[J/OL]. Lancet Oncol, 2015, 16(7): e322-332[2015-12-04]. https://pubmed.ncbi.nlm.nih.gov/26149884/. DOI: 10.1016/S1470-2045(15)00076-5.
49.	中華醫學會眼科學分會眼免疫學組. 中國葡萄膜炎診療中眼內液檢測專家共識(2020年)[J]. 中華眼科雜志, 2020, 56(9): 657-661. DOI: 10.3760/cma.j.cn112142-20200305-00141.The Eye Immunology Group of the Ophthalmology Branch of the Chinese Medical Association. Expert consensus on the detection of intraocular fluid in the diagnosis and treatment of uveitis in China (2020)[J]. Chin J Ophthalmol, 2020, 56(9): 657-661. DOI: 10.3760/cma.j.cn112142-20200305-00141.
50.	Kalogeropoulos D, Vartholomatos G, Mitra A, et al. Primary vitreoretinal lymphoma[J]. Saudi J Ophthalmol, 2019, 33(1): 66-80. DOI: 10.1016/j.sjopt.2018.12.008.
51.	Sagoo MS, Mehta H, Swampillai AJ, et al. Primary intraocular lymphoma[J]. Surv Ophthalmol, 2014, 59(5): 503-516. DOI: 10.1016/j.survophthal.2013.12.001.
52.	Fox CP, Phillips EH, Smith J, et al. Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma[J]. Br J Haematol, 2019, 184(3): 348-363. DOI: 10.1111/bjh.15661.
53.	Garweg JG, de Groot-Mijnes JD, Montoya JG. Diagnostic approach to ocular toxoplasmosis[J]. Ocul Immunol Inflamm, 2011, 19(4): 255-261. DOI: 10.3109/09273948.2011.595872.
54.	de Visser L, Rothova A, de Boer JH, et al. Diagnosis of ocular toxocariasis by establishing intraocular antibody production[J]. Am J Ophthalmol, 2008, 145(2): 369-374. DOI: 10.1016/j.ajo.2007.09.020.
55.	Barba I, Garcia-Ramírez M, Hernández C, et al. Metabolic fingerprints of proliferative diabetic retinopathy: an ¹H-NMR-based metabonomic approach using vitreous humor[J]. Invest Ophthalmol Vis Sci, 2010, 51(9): 4416-4421. DOI: 10.1167/iovs.10-5348.
56.	Haines NR, Manoharan N, Olson JL, et al. Metabolomics analysis of human vitreous in diabetic retinopathy and rhegmatogenous retinal detachment[J]. J Proteome Res, 2018, 17(7): 2421-2427. DOI: 10.1021/acs.jproteome.8b00169.
57.	Jin H, Zhu B, Liu X, et al. Metabolic characterization of diabetic retinopathy: an ¹H-NMR-based metabolomic approach using human aqueous humor[J]. J Pharm Biomed Anal, 2019, 174: 414-421. DOI: 10.1016/j.jpba.2019.06.013.
58.	Noma H, Funatsu H, Mimura T, et al. Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion[J]. Ophthalmology, 2009, 116(1): 87-93. DOI: 10.1016/j.ophtha.2008.09.034.
59.	Wei P, He M, Teng H, et al. Quantitative analysis of metabolites in glucose metabolism in the aqueous humor of patients with central retinal vein occlusion[J/OL]. Exp Eye Res, 2020, 191: 107919[2020-01-08]. https://pubmed.ncbi.nlm.nih.gov/31923416/. DOI: 10.1016/j.exer.2020.107919.
60.	Yao J, Chen Z, Yang Q, et al. Proteomic analysis of aqueous humor from patients with branch retinal vein occlusion-induced macular edema[J]. Int J Mol Med, 2013, 32(6): 1421-1434. DOI: 10.3892/ijmm.2013.1509.
61.	Koban Y, Sahin S, Boy F, et al. Elevated lipocalin-2 level in aqueous humor of patients with central retinal vein occlusion[J]. Int Ophthalmol, 2019, 39(5): 981-986. DOI: 10.1007/s10792-018-0894-2.
62.	Mruthyunjaya P, Jumper JM, McCallum R, et al. Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy[J]. Ophthalmology, 2002, 109(6): 1123-1129. DOI: 10.1016/s0161-6420(02)01033-3.
63.	Malosse L, Angioi K, Baumann C, et al. Vitrectomie diagnostique dans les inflammations intraoculaires: étude d'une série rétrospective[Diagnostic vitrectomy in intraocular inflammations: a retrospective series][J]. J Fr Ophtalmol, 2019, 42(6): 618-625. DOI: 10.1016/j.jfo.2019.03.003.
64.	林海燕, 戴榮平, 林燕楠, 等. 65例診斷不明的葡萄膜炎患者玻璃體切割標本檢查診斷結果分析[J]. 中華眼底病雜志, 2017, 33(4): 404-406. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.018.Lin HY, Dai RP, Lin YN, et al. Use of diagnostic vitrectomy in eyes with uveitis of unknown etiology[J]. Chin J Ocul Fundus Dis, 2017, 33(4): 404-406. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.018.
65.	Hillier RJ, Ojaimi E, Wong DT, et al. Aqueous humor cytokine levels and anatomic response to intravitreal ranibizumab in diabetic macular edema[J]. JAMA Ophthalmol, 2018, 136(4): 382-388. DOI: 10.1001/jamaophthalmol.2018.0179.
66.	Kwon JW, Jee D. Aqueous humor cytokine levels in patients with diabetic macular edema refractory to anti-VEGF treatment[J/OL]. PLoS One, 2018, 13(9): e0203408[2018-09-11]. https://pubmed.ncbi.nlm.nih.gov/30204781/. DOI: 10.1371/journal.pone.0203408.
67.	Wang Y, Fan H, Gao K, et al. Levels of cytokines in the aqueous humor guided treatment of refractory macular edema in adult-onset coats' disease[J/OL]. BMC Ophthalmol, 2020, 20(1): 261[2020-06-30]. https://pubmed.ncbi.nlm.nih.gov/32605612/. DOI: 10.1186/s12886-020-01474-1.
68.	Torres-Costa S, Alves Valente MC, Falc?o-Reis F, et al. Cytokines and growth factors as predictors of response to medical treatment in diabetic macular edema[J]. J Pharmacol Exp Ther, 2020, 373(3): 445-452. DOI: 10.1124/jpet.119.262956.
69.	Urias EA, Urias GA, Monickaraj F, et al. Novel therapeutic targets in diabetic macular edema: beyond VEGF[J]. Vision Res, 2017, 139: 221-227. DOI: 10.1016/j.visres.2017.06.015.
70.	Wang B, Tian B, Tao Y, et al. Continued decline of aqueous interleukin-8 after multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis[J]. J Ocul Pharmacol Ther, 2014, 30(7): 587-592. DOI: 10.1089/jop.2013.0241.
71.	Zhang C, Wang YE, Miao H, et al. Efficacy and safety of aqueous interleukin-8-guided treatment in cytomegalovirus retinitis after bone marrow hematopoietic stem cell transplantation[J]. Ocul Immunol Inflamm, 2020, 16: 1-8. DOI: 10.1080/09273948.2020.1823422.
72.	Miao H, Hou J. Aqueous cytomegalovirus DNA and interleukin-8 determination in management of cytomegalovirus retinitis[J/OL]. Acta Ophthalmol, 2019, 97(3): e483-e484[2018-09-05]. https://pubmed.ncbi.nlm.nih.gov/30187638/. DOI: 10.1111/aos.13787.

1. De Simone L, Belloni L, Aldigeri R, et al. Aqueous tap and rapid diagnosis of cytomegalovirus anterior uveitis: the reggio emilia experience[J]. Graefe's Arch Clin Exp Ophthalmol, 2019, 257(1): 181-186. DOI: 10.1007/s00417-018-4180-9.
2. Martín Ramírez A, Carde?oso Domingo L, González Guijarro JJ. PCR multiplex for CMV detection in patients with anterior uveitis[J]. Ocul Immunol Inflamm, 2019, 27(2): 197-202. DOI: 10.1080/09273948.2018.1438633.
3. Chee SP, Bacsal K, Jap A, et al. Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients[J]. Am J Ophthalmol, 2008, 145(5): 834-840. DOI: 10.1016/j.ajo.2007.12.015.
4. Iyer JV, Agrawal R, Yeo TK, et al. Aqueous humor immune factors and cytomegalovirus (CMV) levels in CMV retinitis through treatment-the CRIGSS study[J]. Cytokine, 2016, 84: 56-62. DOI: 10.1016/j.cyto.2016.05.009.
5. Mitchell SM, Fox JD. Aqueous and vitreous humor samples for the diagnosis of cytomegalovirus retinitis[J]. Am J Ophthalmol, 1995, 120(2): 252-253. DOI: 10.1016/s0002-9394(14)72618-2.
6. Yamamoto N, Wakabayashi T, Murakami K, et al. Detection of CMV DNA in the aqueous humor of AIDS patients with CMV retinitis by AMPLICOR CMV test[J]. Ophthalmologica, 2003, 217(1): 45-48. DOI: 10.1159/000068245.
7. Neumann R, Barequet D, Rosenblatt A, et al. Herpetic anterior uveitis-analysis of presumed and PCR proven cases[J]. Ocul Immunol Inflamm, 2019, 27(2): 211-218. DOI: 10.1080/09273948.2018.1483521.
8. Siverio Júnior CD, Imai Y, Cunningham ET Jr. Diagnosis and management of herpetic anterior uveitis[J]. Int Ophthalmol Clin, 2002, 42(1): 43-48. DOI: 10.1097/00004397-200201000-00007.
9. 郭源源, 朱丹, 陶勇. 急性視網膜壞死的研究進展[J]. 中華眼科醫學雜志(電子版), 2013, 3(4): 236-239. DOI: 10.3877/cma.j.issn.2095-2007.2013.04.013.Guo YY, Zhu D, Tao Y. Research progress on acute retinal necrosis[J]. Chin J Ophthalmol Med (Electronic Edition), 2013, 3(4): 236-239. DOI: 10.3877/cma.j.issn.2095-2007.2013.04.013.
10. Abe T, Tsuchida K, Tamai M. A comparative study of the polymerase chain reaction and local antibody production in acute retinal necrosis syndrome and cytomegalovirus retinitis[J]. Graefe's Arch Clin Exp Ophthalmol, 1996, 234(7): 419-424. DOI: 10.1007/BF02539407.
11. Sugita S, Shimizu N, Watanabe K, et al. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis[J]. Br J Ophthalmol, 2008, 92(7): 928-932. DOI: 10.1136/bjo.2007.133967.
12. 陶勇. 眼內液病原學檢測的研究進展[J]. 中華眼科雜志, 2018, 54(7): 551-556. DOI: 10.3760/cma.j.issn.0412-4081.2018.07.019.Tao Y. Research on examination of intraocular fluid for diagnosis of infectious ocular diseases[J]. Chin J Ophthalmol, 2018, 54(7): 551-556. DOI: 10.3760/cma.j.issn.0412-4081.2018.07.019.
13. Rishi E, Rishi P, Therese KL, et al. Culture and reverse transcriptase polymerase chain reaction (RT-PCR) proven mycobacterium tuberculosis endophthalmitis: a case series[J]. Ocul Immunol Inflamm, 2018, 26(2): 220-227. DOI: 10.1080/09273948.2016.1207786.
14. Durand ML. Bacterial and fungal endophthalmitis[J]. Clin Microbiol Rev, 2017, 30(3): 597-613. DOI: 10.1128/CMR.00113-16.
15. Wittenberg LA, Maberley DA, Ma PE, et al. Contribution of vitreous cytology to final clinical diagnosis fifteen-year review of vitreous cytology specimens from one institution[J]. Ophthalmology, 2008, 115(11): 1944-1950. DOI: 10.1016/j.ophtha.2008.05.022.
16. Oahalou A, Schellekens PA, de Groot-Mijnes JD, et al. Diagnostic pars plana vitrectomy and aqueous analyses in patients with uveitis of unknown cause[J]. Retina, 2014, 34(1): 108-114. DOI: 10.1097/IAE.0b013e31828e6985.
17. Margolis R, Brasil OF, Lowder CY, et al. Vitrectomy for the diagnosis and management of uveitis of unknown cause[J]. Ophthalmology, 2007, 114(10): 1893-1897. DOI: 10.1016/j.ophtha.2007.01.038.
18. Schoenberger SD, Kim SJ, Thorne JE, et al. Diagnosis and treatment of acute retinal necrosis: a report by the American academy of ophthalmology[J]. Ophthalmology, 2017, 124(3): 382-392. DOI: 10.1016/j.ophtha.2016.11.007.
19. Hsiao YT, Kuo MT, Chiang WY, et al. Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction[J/OL]. BMC Ophthalmol, 2019, 19(1): 87[2019-04-03]. https://pubmed.ncbi.nlm.nih.gov/30943921/. DOI: 10.1186/s12886-019-1093-2.
20. Bispo P, Davoudi S, Sahm ML, et al. Rapid detection and identification of uveitis pathogens by qualitative multiplex real-time PCR[J]. Invest Ophthalmol Vis Sci, 2018, 59(1): 582-589. DOI: 10.1167/iovs.17-22597.
21. Bagyalakshmi R, Madhavan HN, Therese KL. Development and application of multiplex polymerase chain reaction for the etiological diagnosis of infectious endophthalmitis[J]. J Postgrad Med, 2006, 52(3): 179-182.
22. Nakano S, Sugita S, Tomaru Y, et al. Establishment of multiplex solid-phase strip PCR test for detection of 24 ocular infectious disease pathogens[J]. Invest Ophthalmol Vis Sci, 2017, 58(3): 1553-1559. DOI: 10.1167/iovs.16-20556.
23. Notomi T, Okayama H, Masubuchi H, et al. Loop-mediated isothermal amplification of DNA[J/OL]. Nucleic Acids Res, 2000, 28(12): E63[2000-06-15]. https://pubmed.ncbi.nlm.nih.gov/10871386/. DOI: 10.1093/nar/28.12.e63.
24. Gudiseva HV, Berry JL, Polski A, et al. Next-generation technologies and strategies for the management of retinoblastoma[J/OL]. Genes (Basel), 2019, 10(12): 1032[2019-12-11]. https://pubmed.ncbi.nlm.nih.gov/31835688/. DOI: 10.3390/genes10121032.
25. Mishra D, Satpathy G, Chawla R, et al. Utility of broad-range 16S rRNA PCR assay versus conventional methods for laboratory diagnosis of bacterial endophthalmitis in a tertiary care hospital[J]. Br J Ophthalmol, 2019, 103(1): 152-156. DOI: 10.1136/bjophthalmol-2018-312877.
26. Srinivasan R, Karaoz U, Volegova M, et al. Use of 16S rRNA gene for identification of a broad range of clinically relevant bacterial pathogens[J/OL]. PLoS One, 2015, 10(2): e0117617[2015-02-06]. https://pubmed.ncbi.nlm.nih.gov/25658760/. DOI: 10.1371/journal.pone.0117617.
27. Ogawa M, Sugita S, Watanabe K, et al. Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA[J]. Graefe's Arch Clin Exp Ophthalmol, 2012, 250(12): 1877-1883. DOI: 10.1007/s00417-012-2015-7.
28. Ruokonen PC, Metzner S, Ucer A, et al. Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis[J]. Graefe's Arch Clin Exp Ophthalmol, 2010, 248(4): 565-571. DOI: 10.1007/s00417-009-1239-7.
29. Kashiwagi K, Gohdo T, Sato S, et al. Detection of HIV-RNA in aqueous humor and subretinal fluid in an HIV carrier with rhegmatogenous retinal detachment[J]. Jpn J Ophthalmol, 2000, 44(6): 687-689. DOI: 10.1016/s0021-5155(00)00278-1.
30. Kolomeyer AM, Murphy KM, Traband A, et al. Beta-D-glucan testing in patients with fungal endophthalmitis[J]. Retina, 2018, 38(4): 650-659. DOI: 10.1097/IAE.0000000000002049.
31. 劉媛. G實驗在早期診斷深部真菌感染中的臨床意義[J]. 臨床醫學工程, 2017, 24(9): 1331-1332. DOI: 10.3969/j.issn.1674-4659.2017.09.1331.Liu Y. Clinical significance of G-test in early diagnosis of deep fungal infection[J]. Clinical Medical & Engineering, 2017, 24(9): 1331-1332. DOI: 10.3969/j.issn.1674-4659.2017.09.1331.
32. 謝莉萍, 劉霆, 孟文彤, 等. 血清半乳甘露聚糖檢測血液病患者侵襲性曲霉菌病的價值[J]. 中華內科雜志, 2006, 45(12): 992-995. DOI: 10.3760/j.issn: 0578-1426.2006.12.007.Xie LP, Liu T, Meng WT, et al. The value of serum galactomannan antigen for detection of invasive aspergillosis in hematological patients[J]. Chinese J Intern Med, 2006, 45(12): 992-995. DOI: 10.3760/j.issn: 0578-1426.2006.12.007.
33. 方靖, 許淑娣. 侵襲性真菌感染患者肺泡灌洗液中半乳甘露聚糖的水平變化及臨床意義[J]. 臨床肺科雜志, 2015, 20(7): 1262-1265. DOI: 10.3969/j.issn.1009-6663.2015.07.032.Fang J, Xu SD. Diagnostic value of galactomannan in bronchoalveolar lavage for invasive fungal disease[J]. Journal of Clinical Pulmonary Medicine, 2015, 20(7): 1262-1265. DOI: 10.3969/j.issn.1009-6663.2015.07.032.
34. Maldonado RF, Sá-Correia I, Valvano MA. Lipopolysaccharide modification in gram-negative bacteria during chronic infection[J]. FEMS Microbiol Rev, 2016, 40(4): 480-493. DOI: 10.1093/femsre/fuw007.
35. Wang ZJ, Zhou M, Cao WJ, et al. Evaluation of the goldmann-witmer coefficient in the immunological diagnosis of ocular toxocariasis[J]. Acta Trop, 2016, 158: 20-23. DOI: 10.1016/j.actatropica.2016.02.013.
36. Wang H, Tao Y. Clinical features and prognostic factors in northern Chinese patients with peripheral granuloma type of ocular toxocariasis: a retrospective cohort study[J]. Ocul Immunol Inflamm, 2020, 13: 1-6. DOI: 10.1080/09273948.2020.1804592.
37. Mathis T, Beccat S, Sève P, et al. Comparison of immunoblotting (IgA and IgG) and the goldmann-witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients[J]. Br J Ophthalmol, 2018, 102(10): 1454-1458. DOI: 10.1136/bjophthalmol-2017-311528.
38. 趙瀟, 顏華. 血管內皮生長因子在外傷性增生性玻璃體視網膜病變發病機制中的作用研究進展[J]. 中華眼底病雜志, 2018, 34(2): 187-190. DOI: 10.3760/cma.j.issn.1005-1015.2018.02.023.Zhao X, Yan H. Role of vascular endothelial growth factor in the pathogenesis of traumatic proliferative vitreoretinopathy[J]. Chin J Ocul Fundus Dis, 2018, 34(2): 187-190. DOI: 10.3760/cma.j.issn.1005-1015.2018.02.023.
39. Morescalchi F, Duse S, Gambicorti E, et al Proliferative vitreoretinopathy after eye injuries: an overexpression of growth factors and cytokines leading to a retinal keloid[J/OL]. Mediators Inflamm, 2013, 2013: 269787[2013-09-30]. https://pubmed.ncbi.nlm.nih.gov/24198445/. DOI: 10.1155/2013/269787.
40. 連海燕, 陳曉, 丁琴, 等. 傳統激光光凝與閾值下微脈沖激光光凝對增生型糖尿病視網膜病變玻璃體液中血管內皮生長因子、白細胞介素-33及一氧化氮濃度的影響[J]. 中華眼底病雜志, 2019, 35(2): 124-128. DOI: 10.3760/cma.j.issn.1005-1015.2019.02.004.Lian HY, Chen X, Ding Q, et al. Effects of conventional laser photocoagulation and subthreshold micropulse laser photocoagulation on concentration of vascular endothelial growth factor, interleukin-33 and NO in vitreous of proliferative diabetic retinopathy eyes[J]. Chin J Ocul Fundus Dis, 2019, 35(2): 124-128. DOI: 10.3760/cma.j.issn.1005-1015.2019.02.004.
41. Holland GN. Standard diagnostic criteria for the acute retinal necrosis syndrome. Executive Committee of the American Uveitis Society[J]. Am J Ophthalmol, 1994, 117(5): 663-667. DOI: 10.1016/s0002-9394(14)70075-3.
42. Takase H, Okada AA, Goto H, et al. Development and validation of new diagnostic criteria for acute retinal necrosis[J]. Jpn J Ophthalmol, 2015, 59(1): 14-20. DOI: 10.1007/s10384-014-0362-0.
43. Winterhalter S, Stuebiger N, Maier AK, et al. Acute retinal necrosis: diagnostic and treatment strategies in Germany[J]. Ocul Immunol Inflamm, 2016, 24(5): 537-543. DOI: 10.3109/09273948.2015.1034375.
44. 浙江省醫學會熱帶病與寄生蟲病分會艾滋病學組. 艾滋病合并巨細胞病毒視網膜炎診治浙江省專家共識[J]. 中華臨床感染病雜志, 2019, 12(5): 331-338. DOI: 10.3760/cma.j.issn.1674-2397.2019.05.002.AIDS Group, Society of Tropical Diseases and Parasitology of Zhejiang Medical Association. Zhejiang expert consensus on diagnosis and treatment of cytomegalovirus retinitis in AIDS patients[J]. Chin J Clin Infect Dis, 2019, 12(5): 331-338. DOI: 10.3760/cma.j.issn.1674-2397.2019.05.002.
45. 余盈盈, 趙明威, 苗恒. 基于房水病毒學和炎性細胞因子檢測的巨細胞病毒性視網膜炎治療模式的初步研究[J]. 中華眼底病雜志, 2020, 36(1): 1-4. DOI: 10.3760/cma.j.issn.1005-1015.2020.01.001.Yu YY, Zhao MW, Miao H. Regime for cytomegalovirus retinitis based on aqueous virology and inflammatory cytokine determination[J]. Chin J Ocul Fundus Dis, 2020, 36(1): 1-4. DOI: 10.3760/cma.j.issn.1005-1015.2020.01.001.
46. 毛菲菲, 孫揮宇, 李丹, 等. 獲得性免疫缺陷綜合征患者前房水巨細胞病毒聚合酶鏈反應檢測[J]. 中華眼底病雜志, 2015, 31(6): 564-566. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.013.Mao FF, Sun HY, Li D, et al. Detection of cytomegalovirus by polymerase chain reaction in aqueous samples from patients with acquired immune deficiency syndrome[J]. Chin J Ocul Fundus Dis, 2015, 31(6): 564-566. DOI: 10.3760/cma.j.issn.1005-1015.2015.06.013.
47. McCann JD, Margolis TP, Wong MG, et al. A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis[J]. Am J Ophthalmol, 1995, 120(2): 219-226. DOI: 10.1016/s0002-9394(14)72610-8.
48. Hoang-Xuan K, Bessell E, Bromberg J, et al. Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology[J/OL]. Lancet Oncol, 2015, 16(7): e322-332[2015-12-04]. https://pubmed.ncbi.nlm.nih.gov/26149884/. DOI: 10.1016/S1470-2045(15)00076-5.
49. 中華醫學會眼科學分會眼免疫學組. 中國葡萄膜炎診療中眼內液檢測專家共識(2020年)[J]. 中華眼科雜志, 2020, 56(9): 657-661. DOI: 10.3760/cma.j.cn112142-20200305-00141.The Eye Immunology Group of the Ophthalmology Branch of the Chinese Medical Association. Expert consensus on the detection of intraocular fluid in the diagnosis and treatment of uveitis in China (2020)[J]. Chin J Ophthalmol, 2020, 56(9): 657-661. DOI: 10.3760/cma.j.cn112142-20200305-00141.
50. Kalogeropoulos D, Vartholomatos G, Mitra A, et al. Primary vitreoretinal lymphoma[J]. Saudi J Ophthalmol, 2019, 33(1): 66-80. DOI: 10.1016/j.sjopt.2018.12.008.
51. Sagoo MS, Mehta H, Swampillai AJ, et al. Primary intraocular lymphoma[J]. Surv Ophthalmol, 2014, 59(5): 503-516. DOI: 10.1016/j.survophthal.2013.12.001.
52. Fox CP, Phillips EH, Smith J, et al. Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma[J]. Br J Haematol, 2019, 184(3): 348-363. DOI: 10.1111/bjh.15661.
53. Garweg JG, de Groot-Mijnes JD, Montoya JG. Diagnostic approach to ocular toxoplasmosis[J]. Ocul Immunol Inflamm, 2011, 19(4): 255-261. DOI: 10.3109/09273948.2011.595872.
54. de Visser L, Rothova A, de Boer JH, et al. Diagnosis of ocular toxocariasis by establishing intraocular antibody production[J]. Am J Ophthalmol, 2008, 145(2): 369-374. DOI: 10.1016/j.ajo.2007.09.020.
55. Barba I, Garcia-Ramírez M, Hernández C, et al. Metabolic fingerprints of proliferative diabetic retinopathy: an ¹H-NMR-based metabonomic approach using vitreous humor[J]. Invest Ophthalmol Vis Sci, 2010, 51(9): 4416-4421. DOI: 10.1167/iovs.10-5348.
56. Haines NR, Manoharan N, Olson JL, et al. Metabolomics analysis of human vitreous in diabetic retinopathy and rhegmatogenous retinal detachment[J]. J Proteome Res, 2018, 17(7): 2421-2427. DOI: 10.1021/acs.jproteome.8b00169.
57. Jin H, Zhu B, Liu X, et al. Metabolic characterization of diabetic retinopathy: an ¹H-NMR-based metabolomic approach using human aqueous humor[J]. J Pharm Biomed Anal, 2019, 174: 414-421. DOI: 10.1016/j.jpba.2019.06.013.
58. Noma H, Funatsu H, Mimura T, et al. Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion[J]. Ophthalmology, 2009, 116(1): 87-93. DOI: 10.1016/j.ophtha.2008.09.034.
59. Wei P, He M, Teng H, et al. Quantitative analysis of metabolites in glucose metabolism in the aqueous humor of patients with central retinal vein occlusion[J/OL]. Exp Eye Res, 2020, 191: 107919[2020-01-08]. https://pubmed.ncbi.nlm.nih.gov/31923416/. DOI: 10.1016/j.exer.2020.107919.
60. Yao J, Chen Z, Yang Q, et al. Proteomic analysis of aqueous humor from patients with branch retinal vein occlusion-induced macular edema[J]. Int J Mol Med, 2013, 32(6): 1421-1434. DOI: 10.3892/ijmm.2013.1509.
61. Koban Y, Sahin S, Boy F, et al. Elevated lipocalin-2 level in aqueous humor of patients with central retinal vein occlusion[J]. Int Ophthalmol, 2019, 39(5): 981-986. DOI: 10.1007/s10792-018-0894-2.
62. Mruthyunjaya P, Jumper JM, McCallum R, et al. Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy[J]. Ophthalmology, 2002, 109(6): 1123-1129. DOI: 10.1016/s0161-6420(02)01033-3.
63. Malosse L, Angioi K, Baumann C, et al. Vitrectomie diagnostique dans les inflammations intraoculaires: étude d'une série rétrospective[Diagnostic vitrectomy in intraocular inflammations: a retrospective series][J]. J Fr Ophtalmol, 2019, 42(6): 618-625. DOI: 10.1016/j.jfo.2019.03.003.
64. 林海燕, 戴榮平, 林燕楠, 等. 65例診斷不明的葡萄膜炎患者玻璃體切割標本檢查診斷結果分析[J]. 中華眼底病雜志, 2017, 33(4): 404-406. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.018.Lin HY, Dai RP, Lin YN, et al. Use of diagnostic vitrectomy in eyes with uveitis of unknown etiology[J]. Chin J Ocul Fundus Dis, 2017, 33(4): 404-406. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.018.
65. Hillier RJ, Ojaimi E, Wong DT, et al. Aqueous humor cytokine levels and anatomic response to intravitreal ranibizumab in diabetic macular edema[J]. JAMA Ophthalmol, 2018, 136(4): 382-388. DOI: 10.1001/jamaophthalmol.2018.0179.
66. Kwon JW, Jee D. Aqueous humor cytokine levels in patients with diabetic macular edema refractory to anti-VEGF treatment[J/OL]. PLoS One, 2018, 13(9): e0203408[2018-09-11]. https://pubmed.ncbi.nlm.nih.gov/30204781/. DOI: 10.1371/journal.pone.0203408.
67. Wang Y, Fan H, Gao K, et al. Levels of cytokines in the aqueous humor guided treatment of refractory macular edema in adult-onset coats' disease[J/OL]. BMC Ophthalmol, 2020, 20(1): 261[2020-06-30]. https://pubmed.ncbi.nlm.nih.gov/32605612/. DOI: 10.1186/s12886-020-01474-1.
68. Torres-Costa S, Alves Valente MC, Falc?o-Reis F, et al. Cytokines and growth factors as predictors of response to medical treatment in diabetic macular edema[J]. J Pharmacol Exp Ther, 2020, 373(3): 445-452. DOI: 10.1124/jpet.119.262956.
69. Urias EA, Urias GA, Monickaraj F, et al. Novel therapeutic targets in diabetic macular edema: beyond VEGF[J]. Vision Res, 2017, 139: 221-227. DOI: 10.1016/j.visres.2017.06.015.
70. Wang B, Tian B, Tao Y, et al. Continued decline of aqueous interleukin-8 after multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis[J]. J Ocul Pharmacol Ther, 2014, 30(7): 587-592. DOI: 10.1089/jop.2013.0241.
71. Zhang C, Wang YE, Miao H, et al. Efficacy and safety of aqueous interleukin-8-guided treatment in cytomegalovirus retinitis after bone marrow hematopoietic stem cell transplantation[J]. Ocul Immunol Inflamm, 2020, 16: 1-8. DOI: 10.1080/09273948.2020.1823422.
72. Miao H, Hou J. Aqueous cytomegalovirus DNA and interleukin-8 determination in management of cytomegalovirus retinitis[J/OL]. Acta Ophthalmol, 2019, 97(3): e483-e484[2018-09-05]. https://pubmed.ncbi.nlm.nih.gov/30187638/. DOI: 10.1111/aos.13787.

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Proper use of examination of intraocular fluid to assist precise diagnosis and treatment of vitreoretinal diseases

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