[Abstract]The pathogenesis of lung adenocarcinoma (LUAD) is closely associated with the aberrant expression of long non-coding RNAs (lncRNAs), whose functions are precisely regulated by the important post-transcriptional modification N6-methyladenosine (m6A). Recent studies have revealed that m6A modification plays a critical role in malignant phenotypes of LUAD, including proliferation, invasion, metastasis, and drug resistance, by influencing the stability, processing, and function of lncRNAs. This review systematically summarizes recent advances in understanding the role of m6A-modified lncRNAs in LUAD, with a focus on the functional mechanisms of the m6A-lncRNA regulatory network in tumor progression. It also discusses their clinical potential as novel biomarkers and therapeutic targets, aiming to provide new theoretical insights for the precise diagnosis and treatment of LUAD.