摘要:目的:總結巨大垂體腺瘤水鈉代謝紊亂的圍手術期處理經驗。方法:對71例巨大垂體腺瘤患者術前及術后1周內每日檢測血、尿電解質水平,以及血、尿滲透壓,判斷失鈉及失水類型。總結不同瘤體大小與手術入路和水鈉紊亂發生率、程度、時間之間的關系。結果:71例巨大垂體腺瘤患者中,出現水鈉代謝紊亂52例,發生率73.2%。腫瘤大小與水鈉紊亂發生率、嚴重程度、發生時間成正比,而手術入路選擇與水鈉代謝紊亂發生無明顯相關。結論:巨大垂體腺瘤患者術后水鈉代謝紊亂的發生與瘤體大小成正相關,其出現時間和表現形式復雜。對水鈉代謝紊亂嚴重患者可適當予以預防性治療,以減少臨床癥狀和不良后果。Abstract: Objective: To summarize the preioperative management experience of metabolic disturbance of water and natrium for patients with giant pituitary adenomas. Methods: The electrolyte and osmotic pressure of blood and urine in patients with giant pituitary adenomas were detected within preoperative and postoperative one week and the type of the metabolic disturbance of water and natrium were determined. The correlation of the different tumor size and surgical approach with the incidence rate, extent and time of the metabolic disturbance was summarized. Results: There were 52 cases with different extent metabolic disturbance of water and natrium in 71 cases of giant pituitary adenomas(73.2%). There were a positive correlation of tumor size with the incidence rate, extent and time of the metabolic disturbance, and a negative correlation of surgical approach with that of the metabolic disturbance. Conclusion: The metabolic disturbance of water and natrium in giant pituitary adenomas was positive correlation with the tumor size, which. is various in emergence time and pattern of manifestation. To reduce the clinical symptoms and adverse consequences, prophylactic treatment may be used in patients with serious metabolic disorder of water and natrium.