The “Expert consensus on the standardized procedure of selective internal radiation therapy with yttrium-90 microspheres for liver malignancies (2024 edition)” is China’s first comprehensive technical guideline document on yttrium-90 microsphere selective internal radiation therapy (90Y-SIRT), developed collaboratively by domestic experts in interventional radiology, hepatobiliary surgery, nuclear medicine, and other related fields. This consensus systematically outlines the standardized requirements for the entire process of 90Y-SIRT, including patient selection, preoperative assessment, dosage calculation, procedural techniques, and postoperative management. This section provides an in-depth interpretation of the consensus's core elements, with a focus on analyzing its innovations and differences compared to international guidelines and previous domestic practices. It highlights the consensus’s guiding value in promoting the safe, standardized, and efficient implementation of this technology in China, offering a reference for clinical practice to physicians across multiple disciplines, including hepatobiliary surgery, interventional radiology, medical oncology, and nuclear medicine, etc.