Objective To review all published evidence about thyroid disease based on Meta-analysis. Methods We thoroughly searched the MEDLINE and Cochrane Library combined with Meta-analysis and thyroid disease as key words. Results Total 22 articles were obtained but only 14 papers reached our aim. Conclusion These studies ranged from etiology of thyroid cancer, levothyroxine treatment, to Graves’ disease and have provided excellent evidences about some clinical questions. But there still are a lot of questions need us study further.