ObjectiveTo explore the rehabilitation treatment of postoperative dysfunction in hepatocellular carcinoma based on digital therapy and its clinical significance. MethodsThe postoperative rehabilitation clinic process of a patient was retrospectively analyzed according to the relevant clinical symptoms and dysfunctions, as well as the postoperative rehabilitation measures based on digital therapy and the patient’s prognosis. ResultsCombined with medical history, physical examination and rehabilitation assessment, the patient had pain, activity intolerance, insomnia, and symptom of anxiety and depression. The physical ability, pain, fatigue condition, symptom of anxiety and depression, and insomnia improved on 1 month after digital therapy-based exercise rehabilitation. ConclusionExercise rehabilitation based on digital therapy can improve the adverse symptoms and dysfunctional condition of patients with certain advantages.