ObjectiveTo conduct a comprehensive review of the latest diagnostic and therapeutic advancements in early warning, regenerative medicine, and digital management for the diabetic foot (DF). Methods Through a systematic review of recent global literature, the paradigm shifts in diabetic foot definitions, artificial intelligence (AI)-driven clinical applications, regenerative strategies, and full-lifecycle management models were evaluated. Results The emergence of “diabetes-related foot disease” and the “remission” status has refocused the clinical attention on proactive prevention. AI has demonstrated high objectivity and consistency in risk stratification, early warning, automated wound quantification, and decision support. Meanwhile, regenerative therapies, particularly mRNA-based treatments and bio-active scaffolds, have emerged as a premier research frontier and a pivotal breakthrough in the repair of refractory wounds. The implementation of full-lifecycle management has effectively achieved a closed-loop continuum of care, spanning from early intervention to clinical remission. Conclusion The field of diabetic foot care is evolving into a new era characterized by the integration of digital intelligence and precision regeneration. Future initiatives should focus on the multidisciplinary-led clinical translation and standardization of emerging technologies to establish a comprehensive, precision management framework aimed at achieving “long-term remission”.