ObjectiveTo investigate association between the nutrition-related indicators and the recurrence of venous thromboembolism (VTE). MethodsThe clinical data from the patients with VTE receiving 3 or 6 months of anticoagulation therapy at the West China Hospital of Sichuan University, from January 2020 to October 2022, were retrospective analyzed. The multivariate logistic regression analysis was used to assess the association between the nutrition-related indicators such as albumin to fibrinogen ratio (AFR) and prognostic nutrition index (PNI) and VTE recurrence. The test level was set as α=0.05. ResultsA total of 141 patients with VTE were enrolled, of whom 12 (8.5%) experienced recurrence within 2 years. The multivariate logistic regression analysis identified several risk factors for recurrence, including diabetes [β=–3.368, OR (95%CI)=0.034 (0.001, 0.920), P=0.044], pulmonary embolism [β=–0.454, OR (95%CI)=0.635 (0.423, 0.954), P=0.029], and decreased AFR [β=–0.454, OR (95%CI)=0.635 (0.423, 0.954), P=0.029], but it was not found that the PNI was associated with VTE recurrence [β=–0.153, OR (95%CI)=0.858 (0.722, 1.020), P=0.083]. ConclusionThe findings of this study indicate that close monitoring for recurrent VTE is warranted in patients with diabetes mellitus, pulmonary embolism, and decreased AFR receiving anticoagulation therapy.
Objective To investigate the relevance of prognostic nutritional index (PNI) and albumin to fibrinogen ratio (AFR) to health-related quality of life in patients with venous thromboembolism (VTE) after 1 year discharge. MethodsThe clinical data from the 292 patients with VTE receiving 3 or 6 months of anticoagulation therapy at the West China Hospital of Sichuan University, from January 2020 to October 2024, were retrospective analyzed. Generalized linear model (Gamma distribution with log link) was used to assess the relationship of PNI, AFR, and their interaction termwith the Global Index Score (GIS) at 1 year discharge. ResultsThe correlation analysis showed that AFR (rs=0.325, P<0.001) and PNI (rs=0.322, P<0.001) were positively correlated with GIS after 1 year discharge. In adjusted generalized linear model controlling for age, education, and comorbidities, pulmonary embolism [without pulmonary embolism vs. pulmonary embolism: MR=0.942, 95%CI (0.897, 0.989), P=0.017], VTE recurrence [without VTE recurrence vs. VTE recurrence: MR=1.236, 95%CI (1.168, 1.308), P<0.001], AFR level [MR=1.038, 95%CI (1.018, 1.059), P<0.001] and PNI level [MR=1.014, 95%CI (1.009, 1.018), P<0.001] were associated with GIS after 1 year discharge, PNI and AFR had significant negative effect on GIS [MR=0.999, 95%CI (0.999, 1.000), P<0.001)]. ConclusionsPNI and AFR are associated with health-related quality of life in VTE patients after 1 year discharge. A non-linear interaction between PNI and AFR suggesting that there is a complicated coordinate regulation between them.