Objective To discuss the way of animal model building of hepaticocholedochostomy(HC) and hepaticojejunostomy(HJ) and to compare the short-term effect. Metheds Twenty-nine dogs were divided randomly into control group(n=5) and the experimental group (stenosis of left hepatic duct, n=24). After 7 weeksof stenosis of left hepatic duct,24 dogs in the experimental group were divided randomly into HC subgroup (n=12) and HJ subgroup (n=12) .The operation time and the blood loss during operation were recorded and the hepatic function was detected.Results The diameter of left hepatic duct was significantly expended after 7 week’s stenosis. Hepaticocholedochostomy took shorter time and lost less blood than hepaticojejunostomy. The dogs in HC subgroup lost less weight than thosein HJ subgroup. In HC and HJ subgroups, the mortality rates were 1/12 and 3/12;the infectious rates of incision were 3/12and 5/12 respectively. Serum levels of total bilirubin and transaminase increased significantly in the 7th week after stenosis of left hepatic duct compared with before stenosis of left hepatic duct. However, Serum levels of total bilirubin and transaminase restored to normallevels after 1 month of HC or HJ.Conclusion It is feasible to establish animal model of bile duct reconstruction on the basis of stricture of bile duct. The dogs undergoing hepaticocholedochostomy have less trauma, better results than the dogs undergoing hepaticojejunostomy. Both hepaticocholedochostomy and hepaticojejunostomy are able to relieve the obstruction of bile duct.
ObjectiveTo compare the early efficacy of microwave ablation (MWA) and radiofrequency ablation (RFA) for the treatment of patients with hepatocellular carcinoma (HCC) complicated with liver cirrhosis. MethodsBased on a propensity score matching (PSM) method, a retrospective analysis was conducted on the clinical data of 199 patients with HCC complicated with liver cirrhosis who underwent ablation therapy at The 900 Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China from January 2017 to December 2023. The operation time, changes in liver function after surgery on day 1 and on month 1, postoperative complications, and recurrence-free survival (RFS) were compared between the MWA group and the RFA group. ResultsBefore PSM, there were 36 cases in the MWA group and 163 cases in the RFA group. After PSM, 35 patients were included in both the MWA group and the RFA group. And there were no statistically significant differences in baseline characteristics between the two groups (P>0.05). The operative time was shorter in the MWA group than that in the RFA group (P=0.002). On postoperative day 1, both alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels increased both the MWA and RFA groups; however, the ALT and AST levels in the MWA group were lower than those in the RFA group (P<0.05). On postoperative month 1, no statistically significant differences were observed in liver function indicators between the two groups (P>0.05). The cumulative 1-year RFS rate was 51.4% for both the MWA group and the RFA group, with no statistically significant difference (P>0.05). The 1-year restricted mean survival time (RMST) was 8.89 months [95%CI (7.68, 10.11) months] in the MWA group and 9.41 months [95%CI (8.14, 10.69) months] in the RFA group, the intergroup difference in RMST was –0.52 months [95%CI (–2.28, 1.24) months], which was not statistically significant (P>0.05). ConclusionThe early efficacy of MWA and RFA for treatment of patients with HCC complicated with liver cirrhosis is comparable, but compared with RFA, MWA has the advantages of shorter operation time and milder acute liver function injury.