Objective To summarize the research and development of vaginal reconstruction with tissue engineering technology. Methods The recent l iterature concerning vaginal reconstruction with tissue engineering technology at home and abroad was extensively reviewed and the research and development were summarized. Results Tissue engineering providesan ideal material as the inner tissue in vaginalplasty. The reconstructed tissue closely resembles native vaginal tissue in the cellular organization and physical properties. The cl inical use of the tissue engineered vagina in vaginoplasty can not be harmful to an organism, and the neovagina has sufficient length and depth. However, the long-term follow-up is needed. Conclusion Vaginal reconstruction with tissue engineering technology may have good application prospects, but further research is required.