Epilepsy is one of the common nervous system diseases in children, due to its complex etiology and diverse seizure types, the current treatment are accompanied by many different side effects. Physical activity refers to any bodily movement that results in energy expenditure above the resting metabolic rate and involves muscle contraction. As a complementary and alternative therapy physical activity has gradually gained attention among epilepsy patients. However, there are still great misconceptions among the society, family members, and even medical personnel about whether children with epilepsy participate in sports, resulting in a low level of physical activity in children and adolescents with epilepsy. Current studies have shown that physical activity has a variety of positive effects, such as the frequency of epileptic seizures, improving the cognitive function of children, and improving the quality of life of patients. It is recommended that children and adolescents with epilepsy should regularly in physical activities to improve their physical and mental health. This article provides a domestic and foreign review from the concept of physical activity, measurement tools, the current situation of physical activity in and adolescents with epilepsy, the positive effect of physical activity on children and adolescents with epilepsy, and the factors affecting physical activity in children and adolescents with epilepsy, etc. in order to provide feasible suggestions for subsequent investigation and research, and to provide reliable basis for the clinical formulation of reasonable individualized programs.