Objective To review the expression of mechano-growth factor (MGF) and its roles in tissue repairs andregeneration. Methods The l iterature about the expression of MGF and its roles in tissue repairs and regeneration in recentyears was reviewed. Results MGF is sensitive to mechanical stimulation and can be expressed in various tissues/cells. MGF isresponsible for satell ite cell activation, myoblast proliferation, and plays important roles in the treatment of muscle coloboma,prevention of myocardial injury, and neuroprotection. Conclusion The important role of MGF in tissue repairs andregeneration has been identified, however, the detailed mechanisms remain unclear up to now and still need a further study.