With the integration of new technologies such as molecular imaging, artificial intelligence, and big data with medical equipment, the role of clinical engineering talents with interdisciplinary knowledge and skills in the medical field is increasingly prominent. Since 2018, West China School of Medicine, Sichuan University has launched an introductory general education course on clinical engineering management for undergraduate students across the university. In response to the national education reform strategy, the course has shifted from a single theoretical teaching model to an “autonomy, cooperation, and inquiry” model, enriching the teaching staff and optimizing the teaching assessment. With 5 years of course practice, the number of course applicants has continued to grow, covering a wider range of subject areas, and students have given good evaluations of their teaching. The exploration and practice of this course provide new strategies for cultivating clinical engineering talents.