【摘要】 目的 探討自體造血干細胞移植（autologous hematopoietic stem cell transplantation，auto-HSCT）治療侵襲性NK/T細胞淋巴瘤的療效。 方法 對我科2005年1月16日收治的1例侵襲性NK/T細胞淋巴瘤患者的造血干細胞移植和隨訪資料進行回顧性分析，并復習國內外相關文獻。 結果 患者為37歲女性，診斷結外鼻型NK/T細胞淋巴瘤，系統性，經CHOAP和ICE方案化學療法、手術、局部放射治療控制病情良好后，采集自體骨髓造血干細胞，行auto-HSCT，預處理方案為全身放射治療+ECy；移植+29 d造血功能即順利重建；移植后密切隨訪，患者一直處于完全緩解，至今已存活67個月。 結論 auto-HSCT治療侵襲性NK/T細胞淋巴瘤療效肯定、可靠。【Abstract】 Objective To explore the therapeutic effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on aggressive NK/T lymphoma. Methods The clinical data of one patient with aggressive NK/T lymphoma diagnosed in January 2005 were retrospectively analyzed, and the relevant domestic literatures were analyzed. Results This thirty-seven-year-old female patient had good disease control after undergoing chemotherapy with CHOAP and ICE regimens, surgery, and locoregional radiotherapy. After that, she had been collected enough bone marrow-derived hematopoietic stem cells, then underwent auto-HSCT with these cells. The conditioning regimen was TBI plus ECy. On the +29th day after transplantation,the hematopoietic reconstruction was successful. During the follow-up period, the patient was in complete remission status all along and her disease-free survival (DFS) was 67 months. Conclusion Auto-HSCT is effective on aggressive NK/T lymphoma.