Objective To analyze and summarize the research status, hotspots, and development trends in the field of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The AECOPD-related literature from 2013 to 2023 was retrieved from the China National Knowledge Infrastructure and Web of Science. Based on bibliometric methods, CiteSpace 6.2.R2 and Excel software were used to analyze the journals, authors, institutions, and keywords of AECOPD-related Chinese and English literature. Results Finally, 802 Chinese literature and 3478 English literature were included. The number of Chinese studies on AECOPD had shown a relatively stable trend in the past decade. The number of English studies on AECOPD showed a fluctuating upward trend, reaching its peak in 2021 and then slightly decreasing. The overall number of studies showed a fluctuating upward trend. Compared to Chinese literature authors, English literature authors collaborated more closely. Prior to 2017, Chinese literature mainly focused on the inflammatory mechanisms, bacterial infections, and antibiotic treatment of AECOPD. From 2017 to 2023, attention had been paid to bacterial resistance, traditional Chinese medicine syndrome types, influencing factors, and prognostic nursing. The pathogenesis of inflammation continued to be closely monitored, while also paying attention to oxidative stress mechanisms. The English literature from 2013 to 2018 mainly focused on the clinical outcomes, clinical trials, pathological studies, and antibiotic treatment of AECOPD, with a particular emphasis on its comorbidities with cardiovascular diseases such as myocardial infarction. From 2019 to 2023, the main focus was on the global burden and medical insurance utilization of AECOPD, as well as its pathogenesis, with a particular emphasis on micro level research on the lung microbiome and cell related aspects. Conclusion At present, the publication volume of AECOPD topics is showing a fluctuating upward trend, the disciplinary fields are constantly expanding, and research hotspots are constantly moving forward, receiving widespread attention both domestically and internationally. The overall development trend of related research is good, and cooperation should be strengthened to conduct more in-depth research.
Objective To evaluate the three-dimensional acetabular orientation in asymptomatic population and patients of developmental dysplasia of the hip (DDH) using a semi-automated measurement software, which provides data for the differential diagnosis, surgical planning, surgical instrument design, and postoperative evaluation of hip related diseases. MethodsEighty-four cases of CT data in asymptomatic population (asymptomatic group) and 47 cases of CT data in DDH patients (DDH group) were collected. There was no significant difference in gender and age (including age of male and female subgroups) between the two groups (P<0.05). MaxTHA, a semi-automatic measurement software, was used to measure acetabular inclination and anteversion, including operative inclination (OI), radiographic inclination (RI), anatomic inclination (AI), operative anteversion (OA), radiographic anteversion (RA), and anatomic anteversion (AA). Comparisons were made between the two populations, between different Crowe classification subgroups, between different gender subgroups, and between left and right sides of acetabula. Results The comparison between asymptomatic group, healthy side of DDH group, and affected side of DDH group showed that there was no significant difference in acetabular orientation between asymptomatic group and healthy side of DDH group (P>0.05). The OI, RI, and AI of affected side of DDH group were significantly higher than those in healthy side of DDH group and asymptomatic group, and AA was significantly lower than that in healthy side of DDH group and asymptomatic group (P<0.05). The comparison between the normal acetabula and DDH acetabula with different Crowe classifications showed that there was no significant difference in the acetabulum orientation between Crowe Ⅰ group and the normal group (P>0.05). The OI, RI, and AI of Crowe Ⅱ, Ⅲ, and Ⅳ groups were significantly higher than those of normal group (P<0.05), the OI of Crowe Ⅲ group, RI and AI of Crowe Ⅳ group were significantly higher than those of Crowe Ⅰ group (P<0.05), the AI of Crowe Ⅳ group was significantly higher than that of Crowe Ⅱ group (P<0.05), and the OA, RA, and AA of Crowe Ⅲ group were significantly lower than other subgroups (P<0.05) except Crowe Ⅰ group. The OA, RA, and AA in asymptomatic female group, and the OA and AI in DDH female group were significantly higher than those in all male groups (P<0.05). The OI, RI, AI, and OA of the right acetabula in asymptomatic male group, and the RI and AI of the right acetabula in asymptomatic female group were significantly higher than those on the left side (P<0.05). ConclusionThere were significant differences in acetabular orientation between asymptomatic and DDH populations, inter-group differences among Crowe classification subgroups, inter-gender differences among subgroups, and bilateral differences among asymptomatic individuals.