This article interprets the 2025 International Wound Infection Institute consensus Therapeutic Wound and Skin Cleansing: Clinical Evidence and Recommendations, which marks a paradigm shift in viewing wound cleansing as a “core therapy” rather than an “ancillary procedure”. It systematically analyzes the definition of “therapeutic wound cleansing”, clarifies its distinction from debridement, and explains the proposed “optimal wound care” theoretical model. The core content involves an evidence-based interpretation and comparative analysis of the 14 recommendations across 5 dimensions: timing/frequency, scope, technique/operational standards, solution selection, and pain management. Finally, considering the current state of clinical practice in China, the article discusses the consensus’s implications for promoting standardized and precise wound care, and suggests directions for future research.