ObjectiveTo discuss the feasibility, safety, and superiority of da Vinci surgery system (DVSS) in liver tumor resection. MethodThe clinical data of 21 patients who underwent DVSS in the liver tumor resection were analyzed retrospectively. ResultsThere were 12 patients with hepatocellular carcinoma (HCC), 1 patient with cholang-iocellular carcinoma, 1 patient with hepatic cirrhosis regenerative nodule, 2 patients with metastatic adenocarcinoma, 2 patients with leiomyosarcoma, and 3 patients with cavernous hemangioma.The operative time was (156.67±92.19) min (60-480 min), the intraoperative blood loss was (585.71±1 076.12) mL (50-5 000 mL), the time of diet recovery was (3.23±1.26) d (2-6 d), and the hospital stay was (10.10±9.02) d (5-47 d).The hospital mortality and morbidity rates were 0(0/21) and 9.52%(2/21) respectively including 1 patient with biliary leakage and 1 patient with abdominal infection. ConclusionThis study demonstrates the feasibility and safety of DVSS in the liver tumor resection and the system has a wide range of application for patients who are suffering from liver tumor.