This article explores the treatment principles of mucormycosis within the framework of international guidelines, systematically reviews the treatment strategies for different clinical types and special populations, as well as the application of surgical and local interventions in different types of mucormycosis, by integrating differences in host status, etiological characteristics, and infection sites of mucormycosis, and referencing the practical experience of hospitals in the Huaxi Mucormycosis Collaboration Network in the diagnosis and treatment of mucormycosis. The aim is to provide reference and guidance for clinical decision-making.