The primary principle of evidence-based medicine is that the best clinical decision-making is derived from clinical problems with combination of patient’s preferences with clinical experience and the best evidence. Evidence-based medicine by its nature, is a specific application on the evaluation of medical hypothesis. It also emphasize the importance of humanism in clinical practice. Our study explored the scientific and humanistic characteristics of evidence-based medicine from the prospective of philosophy, so as to facilitate the extensive application of evidence based practice paradigm in other fields.