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"Timolol" 2 results
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The effcet of topical timolol maleate 0.5% on the coroidal circulation was investigaed in 22 normal subjects using the color Doppler,with one eyes as the timolo-treated eye and the contralateral eye as the auto-control eye in each individual.The result showed that,of the 2 groups of eyes,there was a sighificant increase in time average maximum velocity(TAMX),systolic peak velocity(Vs),and distolic velocity(Vd) in timolol-treated eyes.The resistance index in timolol-treated eyes was lower than in the control eyes(p＜0.05). Significant linear correlation in the timolol-treated eyesfound between perfusion and TAMX.It is thought that the increase in volumetric blood flow rate by timolol is due to two concurrent processes:1.an indrect effect on the choroidal circulation through the increase in perfusion pressure; 2.a dirct effect on choroidal vessels resulting from action of drug on adrenergic receptors that is present in the choroidal vasculature.
（Chin J Ocul Fundus Dis,1996,12: 83- 85）
Release date：2016-09-02 06:21
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Objective Methods of evidence-based medicine were used to make an individualized treatment plan concerning newly diagnosed open-angle glaucoma patient. Methods After clinical problems were put forward, evidence was collected from Cochrane Library (Issue 4, 2009), PubMed (1990 -2009), MEDLINE (1990-2009), EMbase (1990-2009), CBM (1990-2009), and CNKI (1990-2009) according to the search strategy. Subject words were open-angle glaucoma, timolol, latanoprost, trabeculectomy, intraocular pressure, randomized controlled trials, human, meta-analysis, systematic review. Results A total of 221 randomized controlled trials, and 19 systematic reviews were identified. A rational treatment plan was made upon a serious evaluation of the data. After one year follow-up, the plan was proved optimal. Conclusion The treatment efficacy in newly diagnosed open-angle glaucoma has been improved by determining an individualized treatment plan according to evidence-based methods.
Release date：2016-09-07 11:24
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