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局部應用噻嗎心安對人眼脈絡膜血液循環的影響

The effcet of topical timolol maleate 0.5% on the coroidal circulation was investigaed in 22 normal subjects using the color Doppler,with one eyes as the timolo-treated eye and the contralateral eye as the auto-control eye in each individual.The result showed that,of the 2 groups of eyes,there was a sighificant increase in time average maximum velocity(TAMX),systolic peak velocity(Vs),and distolic velocity(Vd) in timolol-treated eyes.The resistance index in timolol-treated eyes was lower than in the control eyes(p＜0.05). Significant linear correlation in the timolol-treated eyesfound between perfusion and TAMX.It is thought that the increase in volumetric blood flow rate by timolol is due to two concurrent processes:1.an indrect effect on the choroidal circulation through the increase in perfusion pressure; 2.a dirct effect on choroidal vessels resulting from action of drug on adrenergic receptors that is present in the choroidal vasculature. （Chin J Ocul Fundus Dis,1996,12: 83- 85）