Objective To investigate the clinical effectiveness of focused ultrasound therapy for non-neoplastic epithelial disorders of vulva. Methods Totally 90 patients with pathologically confirmed non-neoplastic epithelial disorders of vulva were enrolled in the study and randomized to receive ultrasound therapy（60 patients）or spectrum therapy (30 patients). The short-term effectiveness and recurrence rate were assessed in both groups at 6 months after treatment. Results In the ultrasound group, 29 cases were cured, 25 were significantly improved, 6 were improved and 5 experienced recurrence. Whereas, in the control group, 1 case was cured, 25 were significantly improved, 4 remained unchanged and 21 experienced recurrence. The short-term effectiveness of ultrasound therapy was superior to that of spectrum therapy (Z=-6.191, P=0.000). And ultrasound therapy was associated with a significantly lower rate of recurrence (χ2=-37.02, P=0.000). Conclusions The focused ultrasound therapy appears to be an effective approach in the treatment of non-neoplastic epithelial disorders of vulva.