Objective To summarize the developmental process of biomedical materials and regenerative medicine. Methods After reviewing and analyzing the literature concerned, we put forward the developmental direction of biomedical materials and regenerative medicine in the future. Results Biomedical materials developed from the first and second-generations to the third-generation in the 1990s. Regenerative medicine was able to help the injured tissues and organs to be regenerated by the use of the capability of healing themselves. This kind of medicine included the technologies of the stem cells and the cloning, the tissue engineering, the substitute tissues and organs, xenotransplantation and soon. Conclusion The third-generation biomaterials possess the following two properties: degradation and bioactivity; and they can help the body heal itself once implanted. Regenerative medicine is a rapidly advancing field that opens a new and exciting opportunity for completely revolutionary therapeutic modalities and technologies.
Objective To explore the effect of first aid mode based on intelligent chest pain center on the rescue effect of patients with acute myocardial infarction (AMI). Methods AMI patients treated in the Second Hospital of Baoding between May 2020 and September 2023 were retrospectively selected. Patients who received traditional chest pain emergency mode between May 2020 and January 2022 were selected as the control group, and patients who received intelligent chest pain center model between February 2022 and September 2023 were selected as the study group. The first aid success rate, first aid time (first visit time, 120 arrival time, triage evaluation time, venous channel opening time, and electrocardiogram time), treatment timeliness [first medical contact to balloon time (FMC-to-B), door to balloon time (D-to-B), stent placement time, emergency stay time, and hospitalization time], basic vital signs (systolic blood pressure, heart rate, and respiratory rate), incidence of complications and family first aid satisfaction were compared between the two groups. Results A total of 98 patients were included, including 50 in the study group and 48 in the control group. There was no significant difference in the success rate of first aid between the study group and the control group (96.0% vs. 83.3%, P>0.05). The first visit time [(203.15±33.82) vs. (260.71±41.05) min], 120 arrival time [(10.45±1.61) vs. (14.02±2.31) min], triage evaluation time [(1.07±0.21) vs. (1.71±0.33) min], venous channel opening time [(1.31±0.16) vs. (2.95±0.42) min], electrocardiogram time [(5.52±1.08) vs. (6.89±1.38) min], FMC-to-B [(115.82±31.74) vs. (145.29±46.15) min], D-to-B [(78.15±30.41) vs. (112.53±34.12) min], stent placement time [(45.01±8.36) vs. (71.85±9.67) min], emergency stay time [(38.24±9.81) vs. (59.46±11.05) min] and hospitalization time [(12.98±1.27) vs. (15.31±1.80) d] were shorter in the study group than those in the control group (P<0.05). After first aid, the systolic blood pressure [(133.49±13.16) vs. (142.69±12.58) mm Hg (1 mm Hg=0.133 kPa)], heart rate [(90.26±18.25) vs. (103.69±17.49) beats per minute], respiratory rate [(22.15±2.87) vs. (24.87±3.08) breaths per minute] and complication rate (10.4% vs. 27.5%) in the study group were lower than those in the control group (P<0.05). The first aid satisfaction of family members was higher in the study group than that in the control group (97.9% vs. 82.5%, P<0.05). Conclusion The first aid model based on intelligent chest pain center can improve the success rate of first aid treatment for AMI patients, shorten the first aid treatment time, enhance the time effectiveness of treatment, stabilize the basic vital signs of patients, reduce the incidence of complications, and improve the satisfaction of family members with first aid treatment.
Objective To study the clinical and CT findings of bronchiolar adenoma. Methods Patients diagnosed with bronchiolar adenoma confirmed by surgical pathology at Linyi People's Hospital and Yantai Yuhuangding Hospital from 2016 to 2021 were collected. Their clinical and CT imaging features were retrospectively analyzed. ResultsFinally, 25 patients were collected, including 6 males and 19 females, aged 32-73 (58.6±10.1) years. The immunohistochemical Ki-67 (MIB1) of all lesions was <5%. The lesions were located in the upper and middle lobe of both lungs in 9 patients, lower lobes in 16 patients, extrapulmonary zone in 22 patients, intrapulmonary middle zone in 3 patients, round in 11 patients, irregular in 14 patients, well-defined in 22 patients, pure ground-glass/mixed ground-glass nodules in 6 patients, solid nodules in 19 patients. There were 11 patients with central small cavity, 18 patients with single bronchioles sign, 19 patients without adhesion with adjacent pleura, and 24 patients without mediastinal lymph node enlargement. ConclusionBronchiolar adenomas usually occur in the middle-aged and elderly, mostly in the lower lobe of both lungs and the distribution of the peripheral lung field, most of the patients do not have any clinical symptoms, and the postoperative prognosis is good. CT may show large nodules or masses, pure ground-glass/mixed ground-glass nodules, irregular solid nodules and central small cavities. Irregular stellate nodules, central small cavity shadow, and single bronchiolar vascular bundle connected with the lesions are relatively specific imaging findings of bronchiolar adenoma.