Objective To discuss different applications ofanterolateral thigh flap in repairing large skinsoft tissue defects. Methods From January 1997 to July 2004, 27 pitients with large-complex tissue defects were treated using anterolateral thigh flap. The tissue defect was located at face in 9 cases,at cervix in 4 cases, at lower limbs in 6 cases, at vulvae in 4 cases,at hip in 1 case, at groin in 1 case and at breast tissue in 2 cases. The defect area was from 9 cm×8 cm to 20 cm×15 cm and the flap was harvested from 10 cm×8 cm to 33 cm×15 cm. Results Flaps survived in 26 cases after operation, and patients were satisfied with local function and appearance; flap necrosis occurred only in1 case，and the defect was covered with free skin graft after dress exchanges. Twenty-three cases were followed up from 3 months to 2 years. The appearance and the sense of recipient site were similar to the adjacent tissue. No obvious malformation of the donor site was observed. No local recurrence was found in the 6 cases of malignancy during the follow-up from 6 months to 15 months. Conclusion Anterolateral thigh skin flap can provide enough tissue to repair large skinsoft tissue defect,and can be used in different ways. So anterolateral femoral skin flap is an ideal flap in repairing large skinsoft tissue defect.