Mendelian randomization (MR) studies use genetic variants as instrumental variables to explore the effects of exposures on health outcomes. STROBE-MR (strengthening the reporting of observational studies in epidemiology using Mendelian randomization) assists authors in reporting their MR studies clearly and transparently, and helpfully to improve the quality of MR. This paper interpreted the STROBE-MR, aiming to help Chinese scholars better understand, disseminate, and apply it.