This paper proposes a forced oscillation respiration resistance detector which has the characteristics of portable and friendly interface, with remote transmission function. STM32 is used to produce single frequency or complex frequency oscillation signal. In the experiments, the signal was magnified by the power amplifier to drive speaker to generate oscillates airflow into the subject's oral cavity. The analog to digital coverter of STM32 was used to measure the signals obtained by the pressure sensor and the flow sensor, and then the operation parameters were to be displayed on the TFT-LCD touch screen, and could also be transferred to the master computer. Simulated lung and volunteerism were used to verify the reliability of the detector. The test results showed that the system was reliable, and it achieved the significance in respiratory impedance detecting.