Objective To explore the effect of first aid mode based on intelligent chest pain center on the rescue effect of patients with acute myocardial infarction (AMI). Methods AMI patients treated in the Second Hospital of Baoding between May 2020 and September 2023 were retrospectively selected. Patients who received traditional chest pain emergency mode between May 2020 and January 2022 were selected as the control group, and patients who received intelligent chest pain center model between February 2022 and September 2023 were selected as the study group. The first aid success rate, first aid time (first visit time, 120 arrival time, triage evaluation time, venous channel opening time, and electrocardiogram time), treatment timeliness [first medical contact to balloon time (FMC-to-B), door to balloon time (D-to-B), stent placement time, emergency stay time, and hospitalization time], basic vital signs (systolic blood pressure, heart rate, and respiratory rate), incidence of complications and family first aid satisfaction were compared between the two groups. Results A total of 98 patients were included, including 50 in the study group and 48 in the control group. There was no significant difference in the success rate of first aid between the study group and the control group (96.0% vs. 83.3%, P>0.05). The first visit time [(203.15±33.82) vs. (260.71±41.05) min], 120 arrival time [(10.45±1.61) vs. (14.02±2.31) min], triage evaluation time [(1.07±0.21) vs. (1.71±0.33) min], venous channel opening time [(1.31±0.16) vs. (2.95±0.42) min], electrocardiogram time [(5.52±1.08) vs. (6.89±1.38) min], FMC-to-B [(115.82±31.74) vs. (145.29±46.15) min], D-to-B [(78.15±30.41) vs. (112.53±34.12) min], stent placement time [(45.01±8.36) vs. (71.85±9.67) min], emergency stay time [(38.24±9.81) vs. (59.46±11.05) min] and hospitalization time [(12.98±1.27) vs. (15.31±1.80) d] were shorter in the study group than those in the control group (P<0.05). After first aid, the systolic blood pressure [(133.49±13.16) vs. (142.69±12.58) mm Hg (1 mm Hg=0.133 kPa)], heart rate [(90.26±18.25) vs. (103.69±17.49) beats per minute], respiratory rate [(22.15±2.87) vs. (24.87±3.08) breaths per minute] and complication rate (10.4% vs. 27.5%) in the study group were lower than those in the control group (P<0.05). The first aid satisfaction of family members was higher in the study group than that in the control group (97.9% vs. 82.5%, P<0.05). Conclusion The first aid model based on intelligent chest pain center can improve the success rate of first aid treatment for AMI patients, shorten the first aid treatment time, enhance the time effectiveness of treatment, stabilize the basic vital signs of patients, reduce the incidence of complications, and improve the satisfaction of family members with first aid treatment.