Objective To investigate the clinical outlook of hepatic stem cells and its relations with liver cancer. Methods The literatures of recent years on the studies of hepatic stem cells were reviewed. Results Liver cancer may consist of cells of various differentiation grades and it may result from the perodifferentiated hepatic stem cells or abnormal differentiated cells. Conclusion The hypothesis of hepatic stem cells has been identified extensively. Further study maybe helpful for revealing the origin, carcinogenesis of hepatic cancer, and may also be useful for the understanding of the mechanism of metastasis.
Objective To investigate the immunoregulatory effects of immunonutrient ω-3 polyunsaturated fatty acid (PUFA) and its applications in organ transplantation. Methods Relevant literatures of recent years were reviewed. Results The immunoregulatory effects of ω-3 PUFA can inhibit proliferation and activation of the immunocompetent cells including T cell and B cell, reduce cytokine production, modulate immunologic response, improve graft function, pro-long survival, reduce episodes of rejection, and lessen adverse reactions of immunosuppressor.Conclusion ω-3 PUFA should have wide applications in organ transplantation due to its immunoregulatory effects. However, this research should be further studied.
ObjectiveTo summarize the current comparison of the efficacy of different treatments for recurrent hepatocellular carcinoma.MethodTo search the literatures about the comparative studies on the efficacy of different treatments for recurrent hepatocellular carcinoma in recent years and analyze them.ResultsIn the treatment of recurrent hepatocellular carcinoma, percutaneous arterial chemoembolization combined with radiofrequency ablation could improve the survival rate and tumor-free survival rate to some extent, compared with the single use of percutaneous arterial chemoembolization. In the short term, there was no difference in efficacy between radiofrequency ablation and surgical resection, but the local recurrence rate of radiofrequency ablation was higher than that of surgical resection group. Salvage liver transplantation offered potential opportunity to reduce the risk of recurrence and tended to improve long-term survival outcomes, but liver sources were scarce and costly. ConclusionsAt present, there is no systematic staging scheme and treatment system for recurrent hepatocellular carcinoma. At the same time, most studies are retrospective, and more prospective studies are needed to further explore the treatment of recurrent hepatocellular carcinoma.
【摘要】目的探討慢性胰腺炎的診治方法。方法對1997年5月至2002年11月期間所收治并經臨床或病理證實的114例慢性胰腺炎患者的資料進行回顧性分析。結果主要臨床表現為腹痛、體重下降、腹脹和消化不良。影像學特征為胰腺腫塊、假性囊腫、胰管擴張和胰管結石。本組中有60例行外科手術治療，術后發生并發癥4例，死亡1例，其余54例經保守治療癥狀緩解。結論慢性胰腺炎臨床表現和影像學表現變化多樣，應根據病變特點選擇手術方式。
【Abstract】Objective To review the recent advances in the use of marginal liver in liver transplantation. Methods The literatures of recent years on the use of marginal liver for liver transplantation were reviewed and summarized.Results The donors with older age, hemodynamic instability, long stay in the intensive care unit and fatty liver are significantly clinical marginal liver donors.Conclusion Though the use of marginal liver donors negatively influences the results of liver transplantation, marginal liver expands the liver source for liver transplantation with a good result.
Objective To review the development of the liver stem cell transplant for the liver regenerative treatment. Methods The transplantationrelated articles about the stem cell classification, repairing mechanisms, administration routes, and existing problems in the liver regenerative therapies reported in the latest literature were extensively reviewed. Results The related liverrepairing stem cells were found to be inside and outside the liver, i.e., the hepatic stem cells and the nonhepatic stem cells. They could repair the liver by the mechanism of the cell fusion or the celltransdifferentiation. The stem cells could be administrated via the portal vein. However, the application of the liver stem cell transplant was restricted by many related clinical problems. Conclusion Further studies are still needed for an improvement of the clinical feasibility for the stem cell transplantation, especially for the liver stem cell transplantation.