In 2016, the Sichuan University established the “West China National Key Laboratory Innovation Class” to explore a new model for cultivating outstanding undergraduate talents in the field of biomedicine. Through the formation of a multidisciplinary cross-faculty team, strengthening early-stage research practices, refining evaluation and incentive mechanisms, and enhancing professional identity, this class has nurtured biomedical talents with broad interdisciplinary perspectives, multidisciplinary intersections, and innovative thinking. This article summarizes the construction experience and achievements of the “West China National Key Laboratory Innovation Class”, aims at providing a reference for the cultivation of top-tier talents in the field of biomedical sciences in China and promoting the enhancement of the quality of top-tier talent cultivation in foundational disciplines in universities.