目的 通過對白芍總苷治療前后尋常型銀屑病患者血清中白介素（IL）-22水平的研究，探討其治療尋常型銀屑病的作用機制。 方法 2009年10月－2010年8月采用雙抗體夾心酶聯免疫吸附法，檢測30例尋常型銀屑病患者，經白芍總苷治療前后及健康對照組20例外周血清中IL-22濃度的變化，分析其在治療前、后與銀屑病皮損面積和嚴重程度指數（PASI）評分的相關性。 結果 尋常型銀屑病患者血清IL-22濃度[（90.50 ± 51.80）pg/mL]較對照組[（40.10 ± 17.20）pg/mL]升高，白芍總苷治療后血清中IL-22水平[（48.70 ± 23.90）pg/mL]較治療前降低（P＜0.05），并與對照組差異無統計學意義（P＞0.05）；治療前、后患者血清IL-22水平與PASI評分呈正相關。結論 白芍總苷可能通過調節IL-22發揮治療尋常型銀屑病的作用。
Spike recorded by multi-channel microelectrode array is very weak and susceptible to interference, whose noisy characteristic affects the accuracy of spike detection. Aiming at the independent white noise, correlation noise and colored noise in the process of spike detection, combining principal component analysis (PCA), wavelet analysis and adaptive time-frequency analysis, a new denoising method (PCWE) that combines PCA-wavelet (PCAW) and ensemble empirical mode decomposition is proposed. Firstly, the principal component was extracted and removed as correlation noise using PCA. Then the wavelet-threshold method was used to remove the independent white noise. Finally, EEMD was used to decompose the noise into the intrinsic modal function of each layer and remove the colored noise. The simulation results showed that PCWE can increase the signal-to-noise ratio by about 2.67 dB and decrease the standard deviation by about 0.4 μV, which apparently improved the accuracy of spike detection. The results of measured data showed that PCWE can increase the signal-to-noise ratio by about 1.33 dB and reduce the standard deviation by about 18.33 μV, which showed its good denoising performance. The results of this study suggests that PCWE can improve the reliability of spike signal and provide an accurate and effective spike denoising new method for the encoding and decoding of neural signal.