Medical quality and patient safety will be impacted by infection prevention and control directly. There will be many challenges on infection prevention and control, especially in large general hospitals. In the practice of infection prevention and control, the quality control work for infection prevention and control needs to establish a service concept, pay attention to the scientificity and precision of management. Multi-disciplinary team work and evidence-based medical study will also play an important role in infection prevention and control. Overall, quality management of infection prevention and control should be developed scientifically and normatively. Based on the practical experience of infection prevention and control, this article summarizes the experience of infection prevention and control management quality control in the First Affiliated Hospital of Zhengzhou University, in order to provide a reference for the research and management practice of infection prevention and control management quality control strategies.