Medical ethic and publication ethic was more and more and important with the development of trial registration and systematic review registration promoted by the World Health Organization and the Cochrane Collaboration. Chinese Trial Registration and Publication Collaboration (ChiCTRPC) published the first statement to implement trial registration in China. We suggested that trial registration should be combined with ethic review and described the new definition of publication ethic in the second meeting by ChiCTRPC in 2010. In the the third meeting of ChiCTRPC in 2011, Experts from many fields communicated adequately and reached consensus. We summarized the experiences and lessons in the 5 years after the first statement of ChiCTRPC was published. Based on the latest progress of research ethic, publication ethic, trial registration, and systematic review registration, we drafted this explanation document for the second statement of ChiCTRPC to realize good research practice (RGP), good publication practice (GPP), and good translation practice (GTP) by implementing research ethic and publication ethic.