【摘要】 目的 觀察丙泊酚在重癥監護室（ICU） 外科術后對患者的鎮靜效果及作用。 方法 2006年7月-2008年7月，對行外科手術后在ICU觀察室采用丙泊酚鎮靜的45例患者的鎮靜效果、停藥蘇醒時間及給藥前后呼吸、循環參數的變化進行觀察，并與治療前進行比較。 結果 丙泊酚鎮靜起效快，鎮靜治療后大多數患者開始血壓有所下降（Plt;0.05）但不久恢復正常，所有患者心率、呼吸頻率、血氧飽和度無明顯變化（Pgt;0.05），停藥后蘇醒快。 結論 丙泊酚是外科術后患者較理想的鎮靜劑，但應根據患者情況調整給藥速度、劑量及時間。 【Abstract】 Objective To observe the sedative effect of propofol on the patients after surgical operations in intensive care unit (ICU). Methods Forty-five patients underwent the injection with propofol after surgical operations in ICU from July 2006 to July 2008. The sedative efficacy, recovery time after the propofol administration, and changes of respiratory, circulate parameter before and after medication were observed, which were compared with those before the treatment. Results The sedative reactive time of propofol was short. Most of the patients had decreased blood pressure after injection with propofol (Plt;0.05) but recovered soon. The heart rate, respiratory rate, and pulse oxygen saturation did not significantly changed (Pgt;0.05). The recovery time was short after propofol administration was stopped. Conclusion Propofol is an effective sedative for the patients after surgical operations in ICU, but the medicated speed, amount and time according to state of the patients should be adjusted.