ObjectiveTo investigate the practice effect of WeChat on the treatment compliance of patients with hyperlipidaemia in general out-patient department. MethodsFrom June 2012 to May 2013, 178 patients with hyperlipidaemia who could use WeChat software were selected. The patients were randomly divided into the control group (87 patients) and experimental group (91 patients). All the patients were treatment with routine nursing intervention. The experimental group was giving nursing intervention based on WeChat. After 180 days, the compliance score and serum lipid level of the patient were tested and analyzed. ResultsThe score in experimental group on the treatment compliance were as follows:diet:6.57±0.78, take medicine:8.64±1.13, exercise:5.11±0.97, and return visit:5.75±0.74; the percentage effective control of lipid level was 93.4%. The score of the control group on the treatment compliance were as follows diet:4.63±1.23, take medicine:6.91±0.73, exercise:3.98±0.54, and return visit:4.86±0.39; the percentage effective control of lipid level was 57.5%. The difference in the results between two groups is significant (P<0.05). ConclusionApplying WeChat software on nursing intervention for patients with hyperlipidaemia may increase the treatment compliance and enhance the control of serum lipid level.