Acute pharyngitis is a common respiratory disease. The combination of traditional Chinese and Western medicine has been proven effective in alleviating pharyngeal pain and systemic symptoms, as well as reducing the use of antibiotics. However, standardized clinical practice guideline was lacking. To address this, the Ear, Nose and Throat Medicines Research Professional Committee of the China Association of Chinese Medicine, in collaboration with over 20 domestic hospitals, has formed a multidisciplinary expert team of both Chinese and Western medical practitioners. Following the principles, methods, and steps of evidence-based guideline development, we identified clinical issues (three background questions and seven clinical questions) through literature review and expert consensus. Based on existing evidence-based guidelines at domestic and overseas, and the results of systematic reviews/meta-analyses, they considered the quality of evidence, weighed the pros and cons of intervention measures, and took into account patient preferences and values. Through the Delphi expert consensus meeting, we formulated 27 recommendations covering the assessment, laboratory and imaging tests, identification of danger signals, and both Chinese and Western medical treatment and prevention measures for acute pharyngitis.