【摘要】 目的 對原發性腸道非霍奇金淋巴瘤穿孔患者的臨床及病理特征、診治、預后進行探討。 方法 回顧性分析1999年1月-2008年12月診治的17例原發性腸道非霍奇金淋巴瘤穿孔患者的臨床資料。 結果 B細胞型9例，T細胞型8例。17例原發腸道非霍奇金淋巴瘤穿孔患者的穿孔部位:大腸7例，小腸7例，回盲部3例。所有患者均行手術治療。除2例穿孔前行化療的患者以外，其余患者術前均未明確診斷。有14例獲得隨訪結果，6例術后3個月內死亡，術后接受化療者7例，1、2、3年生存率分別為41.2%、 23.6%、11.7%，僅1例生存期超過5年。 結論 原發性腸道非霍奇金淋巴瘤穿孔術前診斷困難，預后極差。【Abstract】 Objective To analyze the clinical features, diagnosis, therapy and prognosis of primary intestinal non-hodgkin′s lymphoma perforation. Methods The clinical data of 17 patients with the primary intestinal non-Hodgkin′s lymphoma perforation from January 1999 to December 2008 were retrospectively analyzed. Results Nine patients had intestinal B-cell lymphoma, and eight had intestinal T-cell lymphoma. The sites of perforation were as follows: colon and rectum in 7 (41.2%), ileum and jejunum in 7 (41.2%), and ileocecal junction in 3 (17.6%). All patients had undergone the operations. The disease was not diagnosed before the operation in all of the patients except for the Two patients had a history of systemic chemotherapy before perforation. A total of 14 patients were followed up, in whom six died within three months after the operation; the survival rate 1, 2, and 3 years after the operation was 41.2%, 23.6%, and 11.7%, respectively in seven patients who had undergone the systemic chemotherapy before the operation; one patients lived more than 5 years. Conclusion The diagnosis of primary colonic malignant lymphoma perforation is difficult; the prognosis is miserable.