目的：探討醒腦靜注射液聯合納絡酮注射液在急性安定中毒治療中的療效。方法：本研究采用醒腦靜注射液聯合納絡酮注射液治療急性安定中毒55例并與單純納絡酮治療的51例進行對照。106例患者均經靜脈血毒物測定為安定中毒；來診時均有意識障礙，平均年齡（30.35±7.95）合并酒精中毒及其他疾病20例，常規給予洗胃、補液、利尿促排泄、糾正電解質失衡、吸氧及抗感染等對癥處理。結果：醒腦靜注射液治療組與對照組患者比較，神志恢復時間(h),治療組(1.73±0.98)顯著短于對照組(3.22±1.38)(P＜0.01)；同組患者就診時與清醒后的神志、呼吸、血壓、心率及瞳孔等臨床指標比較差異有顯著性(P＜0.05)。結論:醒腦靜注射液與納絡酮聯合應用，治療急性安定中毒與對照組比較起效快、療效確定，臨床應用安全可靠。
In recent years, the application of the long read single-molecule sequencing technology in clinical genetics testing has been increasingly widespread. Due to its sequencing process not requiring amplification and its characteristic of single-molecule sequencing and long reads, it has unique advantages compared to traditional molecular genetics testing such as Sanger sequencing, next-generation sequencing and chromosomal microarray. In this article, its application in the detection of chromosomal structural abnormalities, monogenic diseases, and preimplantation genetic testing for monogenic diseases were discussed. Along with a comparative analysis of the advantages and disadvantages of the long read single-molecule sequencing technology in these areas compared to traditional molecular genetics testing techniques. This article preliminarily explores the application prospects and value of the long read single-molecule sequencing technology in clinical genetics testing.