Objective?To review the mechanism of improved revascularization of free fat grafting with adipose-derived stem cells (ADSCs).?Methods?The literature related to the basic researches of ADSCs in free fat grafting and angiogenesis was reviewed.?Results?Angiogenesis is a sequence process in time and space which is regulated by various factors. ADSCs possess the capability of secreting many angiogenic growth factors and differentiating into various lineages.Conclusion?ADSCs affect every process of angiogenesis with clear improved angiogenic effects, however, the mechanisms of angiogenic effects need the further researches.