Objective To introduce the development of the collagen materials in drug release and tissue engineering. Methods Literature review and complex analysis were adopted. Results In recent years, some good progress hasbeen made in the studies of collagen, and study on collagen-based materials has become an investigative hotspot especially in tissue engineering. Some new collagen-based drug delivery andengineered materials have come into clinically-demonstrated moment, which willpromote their clinical applications in tissue repairs.ConclusionCollagen has been considered a good potential material in drug release, especially in the tissue-engineering field. To give collagen new characters we should pay more attention to grafting with different function branches through chemistry technique in the future work, except- moderate cross-linking treatment or commingling withother nature or synthesized macromolecules.