Objective To analysis the research status and hotspot in the field of Kawasaki disease (KD) in recent 10 years. Methods The relevant documents included in the core database of Web of Science from 2010 to 2021 were searched, to analyze the cooperation relationship among authors, countries and institutions by CiteSpace software, analyze the co-occurrence, cluster analysis, dynamic frontier evolution and emergence of keywords, analyze the co citation of cited journals and documents, draw a visual map and analyze. Result A total of 3 041 articles were included, and there were 114 core authors. USA was the core country in the research field of KD, while China occupied a place. University of California, San Diego and Montreal University were the core research institutions. Circulation was the core journal. Keywords formed 7 clusters, and there were a total of 62 emergent words. Conclusions In the past 10 years, the research on KD has shown an upward trend. The research hot spots focus on the diagnosis and treatment, management, pathogenesis, epidemiological research of KD, and the research on Kawasaki-like diseases during the coronavirus disease 2019. Predicting the long-term management of KD, related research on intravenous immunoglobulin resistance and cytokines are the research frontiers in this field.