As the largest barrier organ in the human body, once skin defect occur, it not only affects appearance but also cause clinical problems such as infections. Traditional skin defect repair methods, such as autologous skin transplantation and allogeneic skin transplantation, have shortcomings such as limited donor sources, potential immune rejection, and limited repair effects, and are difficult to meet the individualized treatment needs of complex wounds. Bioprinting technology, as a breakthrough approach in tissue engineering in recent years, can accurately control the spatial distribution of seed cells and biomaterials within scaffolds based on digital models, achieving personalized biomimetic structure of skin tissue. This article aims to summarize the application and research progress of bioprinting technology in skin tissue engineering, providing a theoretical basis for its further clinical application.
ObjectiveTo summarize the research progress of several three-dimensional (3-D) printing scaffold materials in bone tissue engineering. MethodThe recent domestic and international articles about 3-D printing scaffold materials were reviewed and summarized. ResultsCompared with conventional manufacturing methods, 3-D printing has distinctive advantages, such as enhancing the controllability of the structure and increasing the productivity. In addition to the traditional metal and ceramic scaffolds, 3-D printing scaffolds carrying seeding cells and tissue factors as well as scaffolds filling particular drugs for special need have been paid more and more attention. ConclusionsThe development of 3-D printing porous scaffolds have revealed new perspectives in bone repairing. But it is still at the initial stage, more basic and clinical researches are still needed.