Childhood is the key period of psychological and behavioral development of children. The changes of children's psychological behavior during this period have an impact on the psychological and behavioral patterns of adolescents and even adults. Epilepsy is a chronic and recurrent disease, which affect the development emotional behavior problem of children with epilepsy seriously. This paper reviewed the influencing factors, measuring methods and intervention of emotional behavior problems in children with epilepsy so as to alleviate the negative emotion and behavior problems and provide quality of life in children with epilepsy.